Abstract
In the present manuscript, a highly efficient, sensitive, and selective sensor based on thiamine-modified Ag-Cu bimetallic nanoparticles was designed for trace-level determination of 4-aminoantipyrine (4-AAP). The prepared nanocomposite Th@Ag-Cu was characterized by X-ray diffraction (XRD), UV-visible spectroscopy, and field emission scanning electron microscopy (FESEM). The electrochemical behaviour of 4-APP on the Th@Ag-Cu nanocomposite-modified glassy carbon electrode (GCE) was investigated in 0.1 M NaOH solution by square wave voltammetry (SWV). Compared with the bare GCE, the proposed electrode showed improved analytical signal in detecting 4-AAP. Under optimum experimental parameters, the proposed sensor displayed good linear responses to concentrations ranging from 0.01 to 500 mu M. The detection limit and sensitivity were calculated as 0.01 and 1.03 mu A/mu M, respectively. The modified sensing platform exhibited good selectivity, sensitivity and excellent discrimination ability for 4-AAP in the presence of various interfering agents. Moreover, it also offered excellent reproducibility and long-term stability. Hence, the proposed sensor can be a promising candidate for the monitoring of other anti-inflammatory drugs.