Abstract
This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC50 esteems going from 5.1 +/- 1.3 - 78.8 +/- 4.6 mu M/mL. Compound 1 (IC50 =5.1 +/- 1.9 mu M) displayed potent result than standard ibuprofen (IC50 = 11.2 +/- 1.9 mu M). In antiplatelet aggregation assay, five compounds 1, 5, 6, 8 and 11 were observed to be dynamic with IC50 esteems observed in the range of 38.34-255.7 +/- 4.1 mu M, whereas, aspirin (IC50 = 30.3 +/- 2.6 mu M) was used as standard. However, compound 11 was found to be good active for both antiinflammatory and antiplatelet aggregation activities (IC50 = 13.9 +/- 4.9 mu g/mL) (IC50 = 38.60 +/- 3.1 mu M), respectively.