Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Alexandre Gagnon; Maan H Amad; Eric Jolicoeur; Serge Landry; Eric Malenfant; Bruno Simoneau; Christiane Yoakim; Pierre R Bonneau; René Coulombe; Patrick L Deroy; Louise Doyon; JIANMIN Duan; Michel Garneau; Ingrid Guse; Araz Jakalian

doi:10.1016/j.bmcl.2007.06.012

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Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Journal article

Peer reviewed

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

Alexandre Gagnon, Maan H Amad, Eric Jolicoeur, Serge Landry, Eric Malenfant, Bruno Simoneau, Christiane Yoakim, Pierre R Bonneau, René Coulombe, Patrick L Deroy, …

Bioorganic & medicinal chemistry letters, Vol.17(16), pp.4437-4441

15/08/2007

DOI: https://doi.org/10.1016/j.bmcl.2007.06.012

PMID: 17583503

Abstract

Antibiotics. Antiinfectious agents. Antiparasitic agents

Antiviral agents

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

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Title: Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases
Creators - without role: Alexandre Gagnon - Boehringer Ingelheim
Maan H Amad - Boehringer Ingelheim
Eric Jolicoeur - Boehringer Ingelheim
Serge Landry - Boehringer Ingelheim
Eric Malenfant - Boehringer Ingelheim
Bruno Simoneau - Boehringer Ingelheim
Christiane Yoakim - Boehringer Ingelheim
Pierre R Bonneau - Boehringer Ingelheim
René Coulombe - Boehringer Ingelheim
Patrick L Deroy - Boehringer Ingelheim
Louise Doyon - Boehringer Ingelheim
JIANMIN Duan - Boehringer Ingelheim
Michel Garneau - Boehringer Ingelheim
Ingrid Guse - Boehringer Ingelheim
Araz Jakalian - Boehringer Ingelheim
Publication Details: Bioorganic & medicinal chemistry letters, Vol.17(16), pp.4437-4441
Publisher: Elsevier
Identifiers: 9945465108331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article