Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks; John R. B. Perry; Patrick Sulem; Daniel I. Chasman; Nora Franceschini; Chunyan He; Kathryn L. Lunetta; Jenny A. Visser; Enda M. Byrne; Diana L. Cousminer; Daniel F. Gudbjartsson; Tonu Esko; Bjarke Feenstra; Jouke-Jan Hottenga; Daniel L. Koller; Zoltan Kutalik; Peng Lin; Massimo Mangino; Mara Marongiu; Patrick F. McArdle; Albert V. Smith; Lisette Stolk; Sophie H. Van Wingerden; Jing Hua Zhao; Eva Albrecht; Tanguy Corre; Erik Ingelsson; Caroline Hayward; Patrik K. E. Magnusson; Erin N. Smith; Shelia Ulivi; Nicole M. Warrington; Lina Zgaga; Helen Alavere; Najaf Amin; Thor Aspelund; Stefania Bandinelli; Ines Barroso; Gerald S. Berenson; Sven Bergmann; Hannah Blackburn; Eric Boerwinkle; Julie E. Buring; Fabio Busonero; Harry Campbell; Stephen J. Chanock; Wei Chen; Marilyn C. Cornelis; David Couper; Andrea D. Coviello; Pio d'Adamo; Ulf de Faire; Eco J. C. de Geus; Panos Deloukas; Angela Doering; George Davey Smith; Douglas F. Easton; Gudny Eiriksdottir; Valur Emilsson; Johan Eriksson; Luigi Ferrucci; Aaron R. Folsom; Tatiana Foroud; Melissa Garcia; Paolo Gasparini; Frank Geller; Christian Gieger; Vilmundur Gudnason; Per Hall; Susan E. Hankinson; Liana Ferreli; Andrew C. Heath; Dena G. Hernandez; Albert Hofman; Frank B. Hu; Thomas Illig; Marjo-Riitta Jaervelin; Andrew D. Johnson; David Karasik; Kay-Tee Khaw; Douglas P. Kiel; Tuomas O. Kilpelaeinen; Ivana Kolcic; Peter Kraft; Lenore J. Launer; Joop S. E. Laven; Shengxu Li; Jianjun Liu; Daniel Levy; Nicholas G. Martin; Wendy L. McArdle; Mads Melbye; Vincent Mooser; Jeffrey C. Murray; Sarah S. Murray; Michael A. Nalls; Pau Navarro; Mari Nelis; Andrew R. Ness; Kate Northstone; Ben A. Oostra; Munro Peacock; Lyle J. Palmer; Aarno Palotie; Guillaume Pare; Alex N. Parker; Nancy L. Pedersen; Leena Peltonen; Craig E. Pennell; Paul Pharoah; Ozren Polasek; Andrew S. Plump; Anneli Pouta; Eleonora Porcu; Thorunn Rafnar; John P. Rice; Susan M. Ring; Fernando Rivadeneira; Igor Rudan; Cinzia Sala; Veikko Salomaa; Serena Sanna; David Schlessinger; Nicholas J. Schork; Angelo Scuteri; Ayellet V. Segre; Alan R. Shuldiner; Nicole Soranzo; Ulla Sovio; Sathanur R. Srinivasan; David P. Strachan; Mar-Liis Tammesoo; Emmi Tikkanen; Daniela Toniolo; Kim Tsui; Laufey Tryggvadottir; Jonathon Tyrer; Manuela Uda; Rob M. van Dam; Joyce B. J. van Meurs; Peter Vollenweider; Gerard Waeber; Nicholas J. Wareham; Dawn M. Waterworth; Michael N. Weedon; H. Erich Wichmann; Gonneke Willemsen; James F. Wilson; Alan F. Wright; Lauren Young; Guangju Zhai; Wei Vivian Zhuang; Laura J. Bierut; Dorret I. Boomsma; Heather A. Boyd; Laura Crisponi; Ellen W. Demerath; Cornelia M. van Duijn; Michael J. Econs; Tamara B. Harris; David J. Hunter; Ruth J. F. Loos; Andres Metspalu; Grant W. Montgomery; Paul M. Ridker; Tim D. Spector; Elizabeth A. Streeten; Kari Stefansson; Unnur Thorsteinsdottir; Andre G. Uitterlinden; Elisabeth Widen; Joanne M. Murabito; Ken K. Ong; Anna Murray; GIANT Consortium

doi:10.1038/ng.714

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks, John R. B. Perry, Patrick Sulem, Daniel I. Chasman, Nora Franceschini, Chunyan He, Kathryn L. Lunetta, Jenny A. Visser, Enda M. Byrne, Diana L. Cousminer, …

Nature genetics, Vol.42(12), pp.1077-U73

01/12/2010

DOI: https://doi.org/10.1038/ng.714

PMCID: PMC3140055

PMID: 21102462

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P < 5 x 10(-8)) and found suggestive evidence for a further 10 loci (P < 1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

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Title: Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Creators - without role: Cathy E. Elks - Massachusetts Rehabilitation Commission
John R. B. Perry - University of Exeter
Patrick Sulem - deCODE Genet, Reykjavik, Iceland
Daniel I. Chasman - Brigham and Women's Hospital
Nora Franceschini - Supreme Council Of Health
Chunyan He - Indiana University
Kathryn L. Lunetta - Framingham Heart Study
Jenny A. Visser - College Station Medical Center
Enda M. Byrne - College Station Medical Center
Diana L. Cousminer - University of Helsinki
Daniel F. Gudbjartsson - deCODE Genet, Reykjavik, Iceland
Tonu Esko - University of Tartu
Bjarke Feenstra - Veterinary Biological and Research Institute
Jouke-Jan Hottenga - University of Amsterdam
Daniel L. Koller - Indiana University
Zoltan Kutalik - University of Lausanne
Peng Lin - Supreme Council Of Health
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Mara Marongiu - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Patrick F. McArdle - Supreme Council Of Health
Albert V. Smith - Iceland Heart Assoc, Kopavogur, Iceland
Lisette Stolk - College Station Medical Center
Sophie H. Van Wingerden - College Station Medical Center
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Eva Albrecht - Helmholtz Zentrum München
Tanguy Corre - Mylan
Erik Ingelsson - Karolinska Institutet
Caroline Hayward - College Station Medical Center
Patrik K. E. Magnusson - Karolinska Institutet
Erin N. Smith - Scripps Institution of Oceanography
Shelia Ulivi - University of Trieste
Nicole M. Warrington - University of Western Australia
Lina Zgaga - University of Edinburgh
Helen Alavere - University of Tartu
Najaf Amin - College Station Medical Center
Thor Aspelund - Iceland Heart Assoc, Kopavogur, Iceland
Stefania Bandinelli - Florence
Ines Barroso - Wellcome Sanger Institute
Gerald S. Berenson - University of New Orleans
Sven Bergmann - University of Lausanne
Hannah Blackburn - Wellcome Sanger Institute
Eric Boerwinkle - Univ Texas Houston, Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA
Julie E. Buring - Brigham and Women's Hospital
Fabio Busonero - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Harry Campbell - University of Edinburgh
Stephen J. Chanock - NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
Wei Chen - University of New Orleans
Marilyn C. Cornelis - Harvard University
David Couper - Biostat
Andrea D. Coviello - Boston University
Pio d'Adamo - University of Trieste
Ulf de Faire - Karolinska Institutet
Eco J. C. de Geus - University of Amsterdam
Panos Deloukas - Wellcome Sanger Institute
Angela Doering - Helmholtz Zentrum München
George Davey Smith - University of Bristol
Douglas F. Easton - University of Cambridge
Gudny Eiriksdottir - Iceland Heart Assoc, Kopavogur, Iceland
Valur Emilsson - Merck
Johan Eriksson - Natl Inst Hlth & Welf, Helsinki, Finland
Luigi Ferrucci - NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA
Aaron R. Folsom - University of Minnesota
Tatiana Foroud - Indiana University
Melissa Garcia - NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA
Paolo Gasparini - University of Trieste
Frank Geller - Veterinary Biological and Research Institute
Christian Gieger - Helmholtz Zentrum München
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Per Hall - Karolinska Institutet
Susan E. Hankinson - Harvard University
Liana Ferreli - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Andrew C. Heath - Supreme Council Of Health
Dena G. Hernandez - NIA, Neurogenet Lab, Bethesda, MD 20892 USA
Albert Hofman - Netherlands Consortium Healthy Aging, Rotterdam, Netherlands
Frank B. Hu - Harvard University
Thomas Illig - Helmholtz Zentrum München
Marjo-Riitta Jaervelin - University of London
Andrew D. Johnson - Framingham Heart Study
David Karasik - Harvard University
Kay-Tee Khaw - University of Cambridge
Douglas P. Kiel - Harvard University
Tuomas O. Kilpelaeinen - Massachusetts Rehabilitation Commission
Ivana Kolcic - University of Zagreb
Peter Kraft - Harvard University
Lenore J. Launer - NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA
Joop S. E. Laven - Erasmus MC
Shengxu Li - Massachusetts Rehabilitation Commission
Jianjun Liu - Genome Institute of Singapore
Daniel Levy - Framingham Heart Study
Nicholas G. Martin - College Station Medical Center
Wendy L. McArdle - University of Bristol
Mads Melbye - Veterinary Biological and Research Institute
Vincent Mooser - GlaxoSmithKline
Jeffrey C. Murray - University of Iowa
Sarah S. Murray - Scripps Genom Med, La Jolla, CA USA
Michael A. Nalls - NIA, Neurogenet Lab, Intramural Res Program, Bethesda, MD 20892 USA
Pau Navarro - College Station Medical Center
Mari Nelis - University of Tartu
Andrew R. Ness - University of Bristol
Kate Northstone - University of Bristol
Ben A. Oostra - College Station Medical Center
Munro Peacock - Indiana University
Lyle J. Palmer - University of Western Australia
Aarno Palotie - University of Helsinki
Guillaume Pare - Brigham and Women's Hospital
Alex N. Parker - Amgen
Nancy L. Pedersen - Karolinska Institutet
Leena Peltonen - Harvard University
Craig E. Pennell - University of Western Australia
Paul Pharoah - University of Cambridge
Ozren Polasek - University of Zagreb
Andrew S. Plump - Merck Res Lab, Rahway, NJ USA
Anneli Pouta - Natl Inst Hlth & Welf, Helsinki, Finland
Eleonora Porcu - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Thorunn Rafnar - deCODE Genet, Reykjavik, Iceland
John P. Rice - Supreme Council Of Health
Susan M. Ring - University of Bristol
Fernando Rivadeneira - College Station Medical Center
Igor Rudan - University of Edinburgh
Cinzia Sala - Mylan
Veikko Salomaa - Natl Inst Hlth & Welf, Helsinki, Finland
Serena Sanna - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
David Schlessinger - NIA, Gerontol Res Ctr, Bethesda, MD 20892 USA
Nicholas J. Schork - Scripps Institution of Oceanography
Angelo Scuteri - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Ayellet V. Segre - Broad Institute
Alan R. Shuldiner - Supreme Council Of Health
Nicole Soranzo - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Ulla Sovio - University of London
Sathanur R. Srinivasan - University of New Orleans
David P. Strachan - University of London
Mar-Liis Tammesoo - University of Tartu
Emmi Tikkanen - University of Helsinki
Daniela Toniolo - Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy
Kim Tsui - Amgen Inc, Cambridge, MA USA
Laufey Tryggvadottir - Iceland Canc Registry, Reykjavik, Iceland
Jonathon Tyrer - University of Cambridge
Manuela Uda - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Rob M. van Dam - Harvard University
Joyce B. J. van Meurs - College Station Medical Center
Peter Vollenweider - College Station Medical Center
Gerard Waeber - College Station Medical Center
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Dawn M. Waterworth - GlaxoSmithKline
Michael N. Weedon - University of Exeter
H. Erich Wichmann - Helmholtz Zentrum München
Gonneke Willemsen - University of Amsterdam
James F. Wilson - University of Edinburgh
Alan F. Wright - College Station Medical Center
Lauren Young - Amgen Inc, Cambridge, MA USA
Guangju Zhai - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Wei Vivian Zhuang - Boston University
Laura J. Bierut - Supreme Council Of Health
Dorret I. Boomsma - University of Amsterdam
Heather A. Boyd - Veterinary Biological and Research Institute
Laura Crisponi - CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy
Ellen W. Demerath - University of Minnesota
Cornelia M. van Duijn - Netherlands Consortium Healthy Aging, Rotterdam, Netherlands
Michael J. Econs - University of Iceland
Tamara B. Harris - NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA
David J. Hunter - Harvard University
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Andres Metspalu - University of Tartu
Grant W. Montgomery - Massachusetts Rehabilitation Commission
Paul M. Ridker - University of Exeter
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Elizabeth A. Streeten - Supreme Council Of Health
Kari Stefansson - deCODE Genet, Reykjavik, Iceland
Unnur Thorsteinsdottir - deCODE Genet, Reykjavik, Iceland
Andre G. Uitterlinden - College Station Medical Center
Elisabeth Widen - University of Helsinki
Joanne M. Murabito - Framingham Heart Study
Ken K. Ong - Massachusetts Rehabilitation Commission
Anna Murray - University of Exeter
GIANT Consortium
Publication Details: Nature genetics, Vol.42(12), pp.1077-U73
Publisher: Springer Nature
Number of pages: 11
Grant note: Hjartavernd (the Icelandic Heart Association) R01DK058845; U01 DK062418 / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Laboratory of Neurogenetics Faculty of Biology and Medicine of Lausanne, Switzerland N02-HL-6-4278 / Affymetrix Swedish Research Council 068545/Z/02; 076467/Z/05/Z; 077016/Z/05/Z; 89061/Z/09/Z; 079895 / Wellcome Trust Leenaards Foundation 11022; 10118 / Cancer Research UK 108-1080315-0302 / Republic of Croatia Ministry of Science, Education and Sports; Ministry of Science, Education and Sports, Republic of Croatia A7960034; A79801419; A79906588; DP0212016; DP0343921; DP0770096 / Australian Research Council US National Institutes of Health Genes, Environment and Health Initiative; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CZB/4/710 / Chief Scientist Office Royal Society, Royal Swedish Academy of Science; Royal Society 572613; 003209 / National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia U01HG004446 / GENEVA Coordinating Center 904-61-193; 575-25-006; 480-04-004; 56-464-14192; NWO 480-05-003; 175.010.2005.011; 911-03-012; 014-93-015 / Netherlands Organization for Scientific Research; Netherlands Organization for Scientific Research (NWO) Juvenile Diabetes Research Foundation International (JDRF); Juvenile Diabetes Research Foundation Center for Disease Control and Prevention (USA), Centre for Medical Systems Biology (CMSB) 10124 / Cancer Research UK; The Francis Crick Institute; Cancer Research UK Helmholtz Zentrum Munchen-German Research Center for Environmental Health; Helmholtz Association National Institute of Allergy and Infectious Diseases (NIAID); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Egmont Foundation 0855082E / American Heart Association 166067 / Canadian Institutes of Health Research; 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National Institutes of Health Research (NIHR) SF0180142s08 / Estonian Government Swedish Ministry of Higher Education and Research Althingi (the Icelandic Parliament) Chief Scientist Office of the Scottish Government National Institute on Alcohol Abuse and Alcoholism (NIAAA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Swedish Society of Medicine NGFN-2; 01GS0823 / German National Genome Research Network 212111 BBMRI; 205419 ECOGENE; 201413 ENGAGE; HEALTH-F2-2008-201865-GEFOS; HEALTH-F2-2008-35627; HEALTH-F4-2007-201413; HEALTH-F4-2007-201550 HYPERGENES; 245536 OPENGENE; TREAT-OA; QLG2-CT-2002-01254; EU/QLRT-2001-01254; ERC-230374 / European Commision Cariplo Foundation; Fondazione Cariplo Agency of Science, Technology and Research of Singapore (A*STAR); Agency for Science Technology & Research (A*STAR) P30 DK072488 / Clinical Nutrition Research Unit of Maryland HD-061437 / National Institute of Child Health and Human Development; 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Identifiers: 9940515108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article