Abstract
Objective: To determine the thrombotic tendency in Sudanese juvenile acute lymphoblastic leukemia (ALL) patients, and to evaluate hemostatic mechanism in Sudanese pediatric patients with leukemia
Design: This is a prospective analytical case control study.
Setting: Khartoum Radiation and Isotopes Centre during the period of collection from 2014-2015
Subjects: The population comprises 81 male and female pediatric patients.
Intervention: Citrated blood specimens were centrifuged at 1500 g for 10 minutes at room temperature, and then the plasma was separated into two plain containers.
Main outcome measure(s): Prothrombin time, activated partial thromboplastin time, protein C, platelet count and fibrinogen in ALL patients
Results: Prothrombin time and international normalized ratio results of control were reciprocally significant with ALL result revealed that there was a correlation between coagulation parameters and ALL; activated partial thromboplastin time results particularly showed strong significant results. Protein C control result presented significant relation with ALL. However, platelet count showed a significant decrease in ALL. Only two patient's results displayed an increase in D-dimer level that were more than normal range.
Conclusion: We conclude that juvenile ALL patients are at high risk of thrombosis but there was no evidence of existing thrombosis.