Abstract
The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappa B) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappa B-activation and II-6 expression was observed. This points to potential antioxidative qualities of TQ. Copyright (C) 2007 John Wiley & Sons, Ltd.