Abstract
Thyroid disorders especially thyrotoxicosis are commonly associated with hepatic dysfunction but cholestasis is rarely reported. We reported a 31-year lady with thyrotoxicosis-associated steatosis and cholestasis, the serological and the immunological markers were negative for chronic viral hepatitis and autoimmune liver diseases. She had significant improvement of the liver enzymes after treatment with radio active I (131). Over three years follow up, the liver enzymes were fluctuating with the changes in the thyroid status. In conclusion re-evaluation of the liver enzymes after treatment of thyrotoxicosis will differentiate patients with thyrotoxicosis induced hepatic dysfunction from those with underlying liver disease