Abstract
OBJECTIVE: Silver nanopar-ticles (G-AgNPs) improve wound healing by promoting skin cell proliferation and differ-entiation. Therefore, G-AgNPs could act as drug carriers and wound healers in biomedi-cine. The current study aimed to improve skin wound healing using natural, safe G-AgNPs.MATERIALS AND METHODS: The G-Ag-NPs were reduced with ethylcellulose (EC) and incorporated into an oil-in-water cream base. The size, charges, and wavelength were used to characterize the prepared G-AgNPs. Further, the transmission electron microscope (TEM) and the scanning electron microscope (SEM) were used to provide the shape of G-AgNPs. More-over, the skin wound healing was evaluated with the appropriate histopathological techniques in a mouse model with skin injury to prove the cu-rative effects of G-AgNPs which was conduct-ed for 15 days on 45 adult male albino rats. The effectiveness of G-AgNPs-EC cream for treat-ing surgical skin wounds was assessed by his-topathological (HP) examination of hematoxylin and eosin (H&E) stained sections.RESULTS: The produced G-AgNPs-EC showed a size of 183.9 +/- 0.854 nm and a charge of-14.0 +/- 0.351 mV. UV-VIS spectra showed a strong ab-sorption of electromagnetic waves in the visi-ble region at 381 nm. Furthermore, the TEM and SEM showed rounded NPs in nano size of the prepared G-AgNPs-EC. The G-AgNPs cream was pivotal in enhancing wounds' healing proper- ties, improving the formation of wound granu-lation tissue, and enhancing the proliferation of tissue in rats.CONCLUSIONS: The current study showed that G-AgNPs-EC is a new skin wound healer that speeds up healing.