Abstract
Purpose: To evaluate the long-term efficacy and durability of combined intradetrusor botulinum-A toxin (BTX-A), endoscopic treatment of vesicouerteral reflux and anal irrigation for stool incontinence (SI) via a total endoscopic and anal irrigation management (TEAM (R)) approach in patients with myelomeningocele and neuropathic bladder and bowel who did not respond to conservative measures.
Materials and Methods: Fourteen myelomeningocele patients with at least 3 years follow-up were included in the study. All patients have urinary and SI not responded to conservative management. All patients received a cystoscopic intradetrusor injection of 12 U/kg (maximum 300 U) BTX-A. There was vesicoureteral reflux in 22 ureters, and a Deflux (R) injection was completed during the same procedure. SI was managed using trans-anal irrigation, either with a fleet enema or Peristeen (R) system regularly.
Results: After at least 3 years of follow-up, mean maximum bladder capacity increased significantly from 78 +/- 36 ml to 200 +/- 76 ml (P < 0.0001) and the maximum detrusor pressure decreased from 56 +/- 12 cm H2O to 29 +/- 7 cm H2O (P < 0.001). Twenty-one refluxing ureters (95%) showed complete resolution and one persisted. Ten patients (72%) achieved complete dryness between catheterizations. Four patients (28%) went for augmentation cystoplasty, due to progressive hydronephrosis and/or persistent urinary incontinence. Thirteen patients achieved complete stool continence.
Conclusions: Over long-term follow-up, major reconstruction surgery can be avoidable or delayable; the TEAM (R) approach is a minimally invasive, safe, simple, and effective way to achieve upper urinary tract protection and provide urinary and stool continence.