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Traceless chemical ligations from O-acyl serine sites
Journal article   Peer reviewed

Traceless chemical ligations from O-acyl serine sites

Mirna El Khatib, Mohamed Elagawany, Farukh Jabeen, Ekaterina Todadze, Oleg Bol'shakov, Alexander Oliferenko, Levan Khelashvili, Said A. El-Feky, Abdullah Asiri and Alan R. Katritzky
Organic & biomolecular chemistry, Vol.10(25), pp.4836-4838
07/07/2012
DOI: https://doi.org/10.1039/c2ob07050b
PMID: 22635203

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.

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