Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series

Antoine Fages; Kristian Hanghøj; Naveed Khan; Charleen Gaunitz; Andaine Seguin-Orlando; Michela Leonardi; Christian McCrory Constantz; Cristina Gamba; Khaled A.S. Al-Rasheid; Silvia Albizuri; Ahmed H. Alfarhan; Morten Allentoft; Saleh Alquraishi; David Anthony; Nurbol Baimukhanov; James H. Barrett; Jamsranjav Bayarsaikhan; Norbert Benecke; Eloísa Bernáldez-Sánchez; Luis Berrocal-Rangel; Fereidoun Biglari; Sanne Boessenkool; Bazartseren Boldgiv; Gottfried Brem; Dorcas Brown; Joachim Burger; Eric Crubézy; Linas Daugnora; Hossein Davoudi; Peter de Barros Damgaard; María de los Ángeles de Chorro y de Villa-Ceballos; Sabine Deschler-Erb; Cleia Detry; Nadine Dill; Maria do Mar Oom; Anna Dohr; Sturla Ellingvåg; Diimaajav Erdenebaatar; Homa Fathi; Sabine Felkel; Carlos Fernández-Rodríguez; Esteban García-Viñas; Mietje Germonpré; José D. Granado; Jón H. Hallsson; Helmut Hemmer; Michael Hofreiter; Aleksei Kasparov; Mutalib Khasanov; Roya Khazaeli; Pavel Kosintsev; Kristian Kristiansen; Tabaldiev Kubatbek; Lukas Kuderna; Pavel Kuznetsov; Haeedeh Laleh; Jennifer A. Leonard; Johanna Lhuillier; Corina Liesau von Lettow-Vorbeck; Andrey Logvin; Lembi Lõugas; Arne Ludwig; Cristina Luis; Ana Margarida Arruda; Tomas Marques-Bonet; Raquel Matoso Silva; Victor Merz; Enkhbayar Mijiddorj; Bryan K. Miller; Oleg Monchalov; Fatemeh A. Mohaseb; Arturo Morales; Ariadna Nieto-Espinet; Heidi Nistelberger; Vedat Onar; Albína H. Pálsdóttir; Vladimir Pitulko; Konstantin Pitskhelauri; Mélanie Pruvost; Petra Rajic Sikanjic; Anita Rapan Papeša; Natalia Roslyakova; Alireza Sardari; Eberhard Sauer; Renate Schafberg; Amelie Scheu; Jörg Schibler; Angela Schlumbaum; Nathalie Serrand; Aitor Serres-Armero; Beth Shapiro; Shiva Sheikhi Seno; Irina Shevnina; Sonia Shidrang; John Southon; Bastiaan Star; Naomi Sykes; Kamal Taheri; William Taylor; Wolf-Rüdiger Teegen; Tajana Trbojević Vukičević; Simon Trixl; Dashzeveg Tumen; Sainbileg Undrakhbold; Emma Usmanova; Ali Vahdati; Silvia Valenzuela-Lamas; Catarina Viegas; Barbara Wallner; Jaco Weinstock; Victor Zaibert; Benoit Clavel; Sébastien Lepetz; Marjan Mashkour; Agnar Helgason; Kári Stefánsson; Eric Barrey; Eske Willerslev; Alan K. Outram; Pablo Librado; Ludovic Orlando; Institutionen för historiska studier

doi:10.1016/j.cell.2019.03.049

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Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series

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Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series

Antoine Fages, Kristian Hanghøj, Naveed Khan, Charleen Gaunitz, Andaine Seguin-Orlando, Michela Leonardi, Christian McCrory Constantz, Cristina Gamba, Khaled A.S. Al-Rasheid, Silvia Albizuri, …

Cell, Vol.177(6), pp.1419-1435.e31

30/05/2019

DOI: https://doi.org/10.1016/j.cell.2019.03.049

PMCID: PMC6547883

PMID: 31056281

Abstract

ancient DNA

animal breeding

diversity

domestication

equestrian civilizations

extinct lineages

horses

management

mules

selection

Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (≥1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modern legacy of past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN “speed gene,” only rose in popularity within the last millennium. Finally, the development of modern breeding impacted genetic diversity more dramatically than the previous millennia of human management. [Display omitted] •Two now-extinct horse lineages lived in Iberia and Siberia some 5,000 years ago•Iberian and Siberian horses contributed limited ancestry to modern domesticates•Oriental horses have had a strong genetic influence within the last millennium•Modern breeding practices were accompanied by a significant drop in genetic diversity Genome-wide data from 278 ancient equids provide insights into how ancient equestrian civilizations managed, exchanged, and bred horses and indicate vast loss of genetic diversity as well as the existence of two extinct lineages of horses that failed to contribute to modern domestic animals.

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Title: Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series
Creators - without role: Antoine Fages - Lundbeck Foundation
Kristian Hanghøj - Laboratory of Molecular Anthropology and Image Synthesis
Naveed Khan - Abdul Wali Khan University Mardan
Charleen Gaunitz - Lundbeck Foundation
Andaine Seguin-Orlando - Lundbeck Foundation
Michela Leonardi - Lundbeck Foundation
Christian McCrory Constantz - University of Copenhagen
Cristina Gamba - Lundbeck Foundation
Khaled A.S. Al-Rasheid - King Saud University
Silvia Albizuri - Seminari d’Estudis i Recerques Prehistoriques, HAR2017-87695-P, Universitat de Barcelona, Barcelona, Spain
Ahmed H. Alfarhan - King Saud University
Morten Allentoft - Lundbeck Foundation
Saleh Alquraishi - King Saud University
David Anthony - Hartwick College
Nurbol Baimukhanov - Shejire DNA project, 050046 Almaty, Kazakhstan
James H. Barrett - University of Cambridge
Jamsranjav Bayarsaikhan - National University of Mongolia
Norbert Benecke - Deutsches Archäologisches Institut, Zentrale
Eloísa Bernáldez-Sánchez - Instituto Andaluz del Patrimonio Histórico
Luis Berrocal-Rangel - Departamento de Prehistoria y Arqueología, Universidad Autónoma de Madrid, Madrid, Spain
Fereidoun Biglari - Department of Paleolithic, National Museum of Iran, 1136918111, Tehran, Iran
Sanne Boessenkool - University of Oslo
Bazartseren Boldgiv - National University of Mongolia
Gottfried Brem - University of Veterinary Medicine Vienna
Dorcas Brown - Hartwick College
Joachim Burger - Johannes Gutenberg University Mainz
Eric Crubézy - Laboratory of Molecular Anthropology and Image Synthesis
Linas Daugnora - Klaipėda University
Hossein Davoudi - Tarbiat Modares University
Peter de Barros Damgaard - University of Copenhagen
María de los Ángeles de Chorro y de Villa-Ceballos - Centro de Biología Molecular Severo Ochoa
Sabine Deschler-Erb - Integrative prähistorische und naturwissenschaftliche Archäologie (IPNA), 4055 Basel, Switzerland
Cleia Detry - University of Lisbon
Nadine Dill - Integrative prähistorische und naturwissenschaftliche Archäologie (IPNA), 4055 Basel, Switzerland
Maria do Mar Oom - CE3C-Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal
Anna Dohr - Ludwig-Maximilians-Universität München
Sturla Ellingvåg - Explico Foundation, 6900 Florø, Norway
Diimaajav Erdenebaatar - Department of Archaeology
Homa Fathi - University of Tehran
Sabine Felkel - University of Veterinary Medicine Vienna
Carlos Fernández-Rodríguez - University of Leon
Esteban García-Viñas - Universidad Pablo de Olavide
Mietje Germonpré - Royal Belgian Institute of Natural Sciences
José D. Granado - Integrative prähistorische und naturwissenschaftliche Archäologie (IPNA), 4055 Basel, Switzerland
Jón H. Hallsson - Agricultural University of Iceland
Helmut Hemmer - Johannes Gutenberg University Mainz
Michael Hofreiter - University of Potsdam
Aleksei Kasparov - Institute of History of Material Culture
Mutalib Khasanov - Samarkand Institute of Veterinary Medicine
Roya Khazaeli - University of Tehran
Pavel Kosintsev - Institute of Plant and Animal Ecology
Kristian Kristiansen - University of Gothenburg
Tabaldiev Kubatbek - Kyrgyz-Türkish Manas Üniversity
Lukas Kuderna - Institut de Biologia Evolutiva, (CSIC-Universitat Pompeu Fabra), PRBB, Barcelona, Catalonia 08003, Spain
Pavel Kuznetsov - Samara State University of Social Sciences and Education
Haeedeh Laleh - University of Tehran
Jennifer A. Leonard - Estación Biológica de Doñana
Johanna Lhuillier - Archéorient
Corina Liesau von Lettow-Vorbeck - Departamento de Prehistoria y Arqueología, Universidad Autónoma de Madrid, Madrid, Spain
Andrey Logvin - Kostanay State University A Baitursynov
Lembi Lõugas - Tallinn University
Arne Ludwig - Leibniz Institute for Zoo and Wildlife Research
Cristina Luis - Centro Interuniversitário de História das Ciências e da Tecnologia
Ana Margarida Arruda - University of Lisbon
Tomas Marques-Bonet - Pompeu Fabra University
Raquel Matoso Silva - Instituto Universitário de Lisboa (ISCTE-IUL), CIES-IUL, Lisboa, Portugal
Victor Merz - S. Toraighyrov Pavlodar State University
Enkhbayar Mijiddorj - Department of Archaeology
Bryan K. Miller - University of Oxford
Oleg Monchalov - Samara State University of Social Sciences and Education
Fatemeh A. Mohaseb - Department of Osteology, National Museum of Iran, 1136918111, Tehran, Iran
Arturo Morales - Autonomous University of Madrid
Ariadna Nieto-Espinet - Archaeology of Social Dynamics Group (ADS), Institució Milà i Fontanals-Consejo Superior de Investigaciones Científicas (IMF-CSIC), 08001 Barcelona, Spain
Heidi Nistelberger - University of Oslo
Vedat Onar - Istanbul University-Cerrahpaşa
Albína H. Pálsdóttir - University of Oslo
Vladimir Pitulko - Institute of History of Material Culture
Konstantin Pitskhelauri - Tbilisi State University
Mélanie Pruvost - University of Bordeaux
Petra Rajic Sikanjic - Institute for Anthropological Research
Anita Rapan Papeša - Vinkovci Municipal Museum, 32 100 Vinkovci, Croatia
Natalia Roslyakova - Samara State University of Social Sciences and Education
Alireza Sardari - Iranian Center for Archaeological Research (ICAR), Iranian Cultural Heritage, Handicrafts, and Tourism Organization (ICHHTO), 1136918111, Tehran, Iran
Eberhard Sauer - University of Edinburgh
Renate Schafberg - Martin Luther University Halle-Wittenberg
Amelie Scheu - Johannes Gutenberg University Mainz
Jörg Schibler - Integrative prähistorische und naturwissenschaftliche Archäologie (IPNA), 4055 Basel, Switzerland
Angela Schlumbaum - Integrative prähistorische und naturwissenschaftliche Archäologie (IPNA), 4055 Basel, Switzerland
Nathalie Serrand - Archéozoologie et Archéobotanique
Aitor Serres-Armero - Institut de Biologia Evolutiva
Beth Shapiro - University of California, Santa Cruz
Shiva Sheikhi Seno - Department of Osteology, National Museum of Iran, 1136918111, Tehran, Iran
Irina Shevnina - Kostanay State University A Baitursynov
Sonia Shidrang - University of Kashan
John Southon - University of California, Irvine
Bastiaan Star - University of Oslo
Naomi Sykes - University of Nottingham
Kamal Taheri - Kermanshah University of Technology
William Taylor - Max Planck Institute for the Science of Human History
Wolf-Rüdiger Teegen - Ludwig-Maximilians-Universität München
Tajana Trbojević Vukičević - University of Zagreb
Simon Trixl - Institute of Palaeoanatomy, Domestication Research and History of Veterinary Medicine, Ludwig-Maximilians-University Munich, 80539 München, Germany
Dashzeveg Tumen - National University of Mongolia
Sainbileg Undrakhbold - National University of Mongolia
Emma Usmanova - Arheološki Institut
Ali Vahdati - Iranian Center for Archaeological Research (ICAR), Iranian Cultural Heritage, Handicrafts, and Tourism Organization (ICHHTO), 1136918111, Tehran, Iran
Silvia Valenzuela-Lamas - Archaeology of Social Dynamics Group (ADS), Institució Milà i Fontanals-Consejo Superior de Investigaciones Científicas (IMF-CSIC), 08001 Barcelona, Spain
Catarina Viegas - Uniarq, Centro de Arqueologia da Universidade de Lisboa, Faculdade de Letras da Universidade de Lisboa, 1600-214 Lisboa, Portugal
Barbara Wallner - University of Vienna
Jaco Weinstock - University of Southampton
Victor Zaibert - Al-Farabi Kazakh National University
Benoit Clavel - Centre National pour la Recherche Scientifique et Technique (CNRST)
Sébastien Lepetz - Centre National pour la Recherche Scientifique et Technique (CNRST)
Marjan Mashkour - Department of Osteology, National Museum of Iran, 1136918111, Tehran, Iran
Agnar Helgason - deCODE Genetics
Kári Stefánsson - deCODE Genetics
Eric Barrey - GABI UMR1313, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
Eske Willerslev - University of Copenhagen
Alan K. Outram - University of Exeter
Pablo Librado - Université de Toulouse
Ludovic Orlando - Université de Toulouse
Institutionen för historiska studier
Publication Details: Cell, Vol.177(6), pp.1419-1435.e31
Publisher: Elsevier Inc
Identifiers: 9946792408331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article