Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Norihiro Kato; Marie Loh; Fumihiko Takeuchi; Niek Verweij; Xu Wang; Weihua Zhang; Tanika N. Kelly; Danish Saleheen; Benjamin Lehne; Irene Mateo Leach; Alexander W. Drong; James Abbott; Simone Wahl; Sian-Tsung Tan; William R. Scott; Gianluca Campanella; Marc Chadeau-Hyam; Uzma Afzal; Tarunveer S. Ahluwalia; Marc Jan Bonder; Peng Chen; Abbas Dehghan; Todd L. Edwards; Tonu Esko; Min Jin Go; Sarah E. Harris; Jaana Hartiala; Silva Kasela; Anuradhani Kasturiratne; Chiea-Chuen Khor; Marcus E. Kleber; Huaixing Li; Zuan Yu Mok; Masahiro Nakatochi; Nur Sabrina Sapari; Richa Saxena; Alexandre F. R. Stewart; Lisette Stolk; Yasuharu Tabara; Ai Ling Teh; Ying Wu; Jer-Yuarn Wu; Yi Zhang; Imke Aits; Alexessander Da Silva Couto Alves; Shikta Das; Rajkumar Dorajoo; Jemma C. Hopewell; Yun Kyoung Kim; Robert W. Koivula; Jian'an Luan; Leo-Pekka Lyytikainen; Quang N. Nguyen; Mark A. Pereira; Iris Postmus; Olli T. Raitakari; Molly Scannell Bryan; Robert A. Scott; Rossella Sorice; Vinicius Tragante; Michela Traglia; Jon White; Ken Yamamoto; Yonghong Zhang; Linda S. Adair; Alauddin Ahmed; Koichi Akiyama; Rasheed Asif; Tin Aung; Ines Barroso; Andrew Bjonnes; Timothy R. Braun; Hui Cai; Li-Ching Chang; Chien-Hsiun Chen; Ching-Yu Cheng; Yap-Seng Chong; Rory Collins; Regina Courtney; Gail Davies; Graciela Delgado; Loi D. Do; Pieter A. Doevendans; Ron T. Gansevoort; Yu-Tang Gao; Tanja B. Grammer; Niels Grarup; Jagvir Grewal; Dongfeng Gu; Gurpreet S. Wander; Anna-Liisa Hartikainen; Stanley L. Hazen; Jing He; Chew-Kiat Heng; James E. Hixson; Albert Hofman; Chris Hsu; Wei Huang; Lise L. N. Husemoen; Joo-Yeon Hwang; Sahoko Ichihara; Michiya Igase; Masato Isono; Johanne M. Justesen; Tomohiro Katsuy; Muhammad G. Kibriya; Young Jin Kim; Miyako Kishimoto; Woon-Puay Koh; Katsuhiko Kohara; Meena Kumari; Kenneth Kwek; Nanette R. Lee; Jeannette Lee; Jiemin Liao; Wolfgang Lieb; David C. M. Liewald; Tatsuaki Matsubara; Yumi Matsushita; Thomas Meitinger; Evelin Mihailov; Lili Milani; Rebecca Mills; Nina Mononen; Martina Mueller-Nurasyid; Toru Nabika; Eitaro Nakashima; Hong Kiat Ng; Kjell Nikus; Teresa Nutile; Takayoshi Ohkubo; Keizo Ohnaka; Sarah Parish; Lavinia Paternoster; Hao Peng; Annette Peters; Son T. Pham; Mohitha J. Pinidiyapathirage; Mahfuzar Rahman; Hiromi Rakugi; Olov Rolandsson; Michelle Ann Rozario; Daniela Ruggiero; Cinzia F. Sala; Ralhan Sarju; Kazuro Shimokawa; Harold Snieder; Thomas Sparso; Wilko Spiering; John M. Starr; David J. Stott; Daniel O. Stram; Takao Sugiyama; Silke Szymczak; W. H. Wilson Tang; Lin Tong; Stella Trompet; Vaino Turjanmaa; Hirotsugu Ueshima; Andre G. Uitterlinden; Satoshi Umemura; Marja Vaarasmaki; Rob M. van Dam; Wiek H. van Gilst; Dirk J. van Veldhuisen; Jorma S. Viikari; Melanie Waldenberger; Yiqin Wang; Aili Wang; Rory Wilson; Tien-Yin Wong; Yong-Bing Xiang; Shuhei Yamaguchi; Xingwang Ye; Robin D. Young; Terri L. Young; Jian-Min Yuan; Xueya Zhou; Folkert W. Asselbergs; Marina Ciullo; Robert Clarke; Panos Deloukas; Andre Franke; Paul W. Franks; Steve Franks; Yechiel Friedlander; Myron D. Gross; Zhirong Guo; Torben Hansen; Marjo-Riitta Jarvelin; Torben Jorgensen; J. Wouter Jukema; Mika Kahonen; Hiroshi Kajio; Mika Kivimaki; Jong-Young Lee; Terho Lehtimaki; Allan Linneberg; Tetsuro Miki; Oluf Pedersen; Nilesh J. Samani; Thorkild I. A. Sorensen; Ryoichi Takayanagi; Daniela Toniolo; Habibul Ahsan; Hooman Allayee; Yuan-Tsong Chen; John Danesh; Ian J. Deary; Oscar H. Franco; Lude Franke; Bastiaan T. Heijman; Joanna D. Holbrook; Aaron Isaacs; Bong-Jo Kim; Xu Lin; Jianjun Liu; Winfried Maerz; Andres Metspalu; Karen L. Mohlke; Dharambir K. Sanghera; Xiao-Ou Shu; Joyce B. J. van Meurs; Eranga Vithana; Ananda R. Wickremasinghe; Cisca Wijmenga; Bruce H. W. Wolffenbuttel; Mitsuhiro Yokota; Wei Zheng; Dingliang Zhu; Paolo Vineis; Soterios A. Kyrtopoulos; Jos C. S. Kleinjans; Mark I. McCarthy; Richie Soong; Christian Gieger; James Scott; Yik-Ying Teo; Jiang He; Paul Elliott; E. Shyong Tai; Pim van der Harst; Jaspal S. Kooner; John C. Chambers; InterAct Consortium

doi:10.1038/ng.3405

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang, Weihua Zhang, Tanika N. Kelly, Danish Saleheen, Benjamin Lehne, Irene Mateo Leach, …

Nature genetics, Vol.47(11), pp.1282-1293

01/11/2015

DOI: https://doi.org/10.1038/ng.3405

PMCID: PMC4719169

PMID: 26390057

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 x 10(-11) to 5.0 x 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 x 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.

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Title: Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Creators - without role: Norihiro Kato - College Station Medical Center
Marie Loh - University of Oulu
Fumihiko Takeuchi - College Station Medical Center
Niek Verweij - University of Groningen
Xu Wang - Supreme Council Of Health
Weihua Zhang - University of London
Tanika N. Kelly - Tulane University
Danish Saleheen - Ctr Non Communicable Dis, Karachi, Pakistan
Benjamin Lehne - University of London
Irene Mateo Leach - University of Groningen
Alexander W. Drong - University of Oxford
James Abbott - University of London
Simone Wahl - Helmholtz Zentrum München
Sian-Tsung Tan - Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England
William R. Scott - University of London
Gianluca Campanella - University of London
Marc Chadeau-Hyam - University of London
Uzma Afzal - University of London
Tarunveer S. Ahluwalia - University of Copenhagen
Marc Jan Bonder - University of Groningen
Peng Chen - Supreme Council Of Health
Abbas Dehghan - College Station Medical Center
Todd L. Edwards - Vanderbilt University
Tonu Esko - University of Tartu
Min Jin Go - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea
Sarah E. Harris - University of Edinburgh
Jaana Hartiala - Supreme Council Of Health
Silva Kasela - University of Tartu
Anuradhani Kasturiratne - University of Kelaniya
Chiea-Chuen Khor - Supreme Council Of Health
Marcus E. Kleber - University of Mannheim
Huaixing Li - Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China
Zuan Yu Mok - Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore
Masahiro Nakatochi - Nagoya University
Nur Sabrina Sapari - Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore
Richa Saxena - Harvard University
Alexandre F. R. Stewart - University of Ottawa
Lisette Stolk - College Station Medical Center
Yasuharu Tabara - Kyoto University
Ai Ling Teh - ASTAR, Singapore Inst Clin Sci, Singapore, Singapore
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Jer-Yuarn Wu - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Yi Zhang - Shanghai Jiao Tong University
Imke Aits - Univ Kiel, Inst Epidemiol & Biobank Popgen, Kiel, Germany
Alexessander Da Silva Couto Alves - University of London
Shikta Das - University of London
Rajkumar Dorajoo - Genome Institute of Singapore
Jemma C. Hopewell - University of Oxford
Yun Kyoung Kim - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea
Robert W. Koivula - Skane Univ, Hosp Malmo, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden
Jian'an Luan - University of Cambridge
Leo-Pekka Lyytikainen - Fimlab
Quang N. Nguyen - Marine Acoustics
Mark A. Pereira - University of Minnesota
Iris Postmus - Leiden University
Olli T. Raitakari - College Station Medical Center
Molly Scannell Bryan - University of Chicago
Robert A. Scott - University of Cambridge
Rossella Sorice - CNR, Inst Genet & Biophys Buzzati Traverso, I-80125 Naples, Italy
Vinicius Tragante - College Station Medical Center
Michela Traglia - Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy
Jon White - UCL, Genet Inst, Dept Genet Environm & Evolut, London, England
Ken Yamamoto - Kyushu University
Yonghong Zhang - Soochow Univ, Coll Med, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Alauddin Ahmed - University of Chicago
Koichi Akiyama - College Station Medical Center
Rasheed Asif - Ctr Non Communicable Dis, Karachi, Pakistan
Tin Aung - Singapore Eye Research Institute
Ines Barroso - Wellcome Sanger Institute
Andrew Bjonnes - Harvard University
Timothy R. Braun - University of Oklahoma
Hui Cai - Vanderbilt University
Li-Ching Chang - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Chien-Hsiun Chen - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Ching-Yu Cheng - Supreme Council Of Health
Yap-Seng Chong - ASTAR, Singapore Inst Clin Sci, Singapore, Singapore
Rory Collins - University of Oxford
Regina Courtney - Vanderbilt University
Gail Davies - University of Edinburgh
Graciela Delgado - University of Mannheim
Loi D. Do - Marine Acoustics
Pieter A. Doevendans - College Station Medical Center
Ron T. Gansevoort - University of Groningen
Yu-Tang Gao - Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China
Tanja B. Grammer - University of Mannheim
Niels Grarup - University of Copenhagen
Jagvir Grewal - University of London
Dongfeng Gu - College Station Medical Center
Gurpreet S. Wander - College Station Medical Center
Anna-Liisa Hartikainen - Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu, Finland
Stanley L. Hazen - College Station Medical Center
Jing He - Vanderbilt University
Chew-Kiat Heng - Supreme Council Of Health
James E. Hixson - Supreme Council Of Health
Albert Hofman - College Station Medical Center
Chris Hsu - Supreme Council Of Health
Wei Huang - Chinese Natl Human Genom Ctr, Dept Genet, Shanghai, Peoples R China
Lise L. N. Husemoen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Joo-Yeon Hwang - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea
Sahoko Ichihara - Mie University
Michiya Igase - Ehime University
Masato Isono - College Station Medical Center
Johanne M. Justesen - University of Copenhagen
Tomohiro Katsuy - Osaka University
Muhammad G. Kibriya - University of Chicago
Young Jin Kim - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea
Miyako Kishimoto - College Station Medical Center
Woon-Puay Koh - Supreme Council Of Health
Katsuhiko Kohara - Ehime University
Meena Kumari - UCL, Dept Epidemiol & Publ Hlth, London, England
Kenneth Kwek - KK Womens & Childrens Hosp, Singapore, Singapore
Nanette R. Lee - University of San Carlos
Jeannette Lee - Supreme Council Of Health
Jiemin Liao - Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore
Wolfgang Lieb - Univ Kiel, Inst Epidemiol & Biobank Popgen, Kiel, Germany
David C. M. Liewald - University of Edinburgh
Tatsuaki Matsubara - Aichi Gakuin University
Yumi Matsushita - College Station Medical Center
Thomas Meitinger - Helmholtz Zenntrum Munchen, German Res Ctr Environm Hlth, Inst Human Genet, Neuherberg, Germany
Evelin Mihailov - University of Tartu
Lili Milani - University of Tartu
Rebecca Mills - Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England
Nina Mononen - Fimlab
Martina Mueller-Nurasyid - Helmholtz Zenntrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany
Toru Nabika - Shimane University
Eitaro Nakashima - Nagoya University
Hong Kiat Ng - Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore
Kjell Nikus - Tampere University
Teresa Nutile - CNR, Inst Genet & Biophys Buzzati Traverso, I-80125 Naples, Italy
Takayoshi Ohkubo - Teikyo University
Keizo Ohnaka - Kyushu University
Sarah Parish - University of Oxford
Lavinia Paternoster - University of Bristol
Hao Peng - Soochow Univ, Coll Med, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
Annette Peters - Helmholtz Zentrum München
Son T. Pham - Marine Acoustics
Mohitha J. Pinidiyapathirage - University of Kelaniya
Mahfuzar Rahman - University of Chicago
Hiromi Rakugi - Osaka University
Olov Rolandsson - Umeå University
Michelle Ann Rozario - Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore
Daniela Ruggiero - CNR, Inst Genet & Biophys Buzzati Traverso, I-80125 Naples, Italy
Cinzia F. Sala - Mylan
Ralhan Sarju - College Station Medical Center
Kazuro Shimokawa - College Station Medical Center
Harold Snieder - University of Groningen
Thomas Sparso - University of Copenhagen
Wilko Spiering - College Station Medical Center
John M. Starr - University of Edinburgh
David J. Stott - University of Glasgow
Daniel O. Stram - Supreme Council Of Health
Takao Sugiyama - Asahi Life Fdn, Inst Adult Dis, Tokyo, Japan
Silke Szymczak - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
W. H. Wilson Tang - College Station Medical Center
Lin Tong - University of Chicago
Stella Trompet - Leiden University
Vaino Turjanmaa - Tampere University
Hirotsugu Ueshima - Shiga University
Andre G. Uitterlinden - College Station Medical Center
Satoshi Umemura - Yokohama City University
Marja Vaarasmaki - Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu, Finland
Rob M. van Dam - Supreme Council Of Health
Wiek H. van Gilst - University of Groningen
Dirk J. van Veldhuisen - University of Groningen
Jorma S. Viikari - College Station Medical Center
Melanie Waldenberger - Helmholtz Zentrum München
Yiqin Wang - Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China
Aili Wang - Soochow Univ, Coll Med, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
Rory Wilson - Helmholtz Zentrum München
Tien-Yin Wong - Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore
Yong-Bing Xiang - Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China
Shuhei Yamaguchi - Shimane University
Xingwang Ye - Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China
Robin D. Young - University of Cambridge
Terri L. Young - Supreme Council Of Health
Jian-Min Yuan - University of Pittsburgh
Xueya Zhou - Tsinghua University
Folkert W. Asselbergs - College Station Medical Center
Marina Ciullo - CNR, Inst Genet & Biophys Buzzati Traverso, I-80125 Naples, Italy
Robert Clarke - University of Oxford
Panos Deloukas - Queen Mary University of London
Andre Franke - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Paul W. Franks - Skane Univ, Hosp Malmo, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden
Steve Franks - University of London
Yechiel Friedlander - Hebrew University of Jerusalem
Myron D. Gross - University of Minnesota
Zhirong Guo - Soochow Univ, Coll Med, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China
Torben Hansen - University of Copenhagen
Marjo-Riitta Jarvelin - University of Oulu
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
J. Wouter Jukema - Leiden University
Mika Kahonen - Tampere University
Hiroshi Kajio - College Station Medical Center
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London, England
Jong-Young Lee - Minist Hlth & Welf, Seoul, South Korea
Terho Lehtimaki - Fimlab
Allan Linneberg - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Tetsuro Miki - Ehime University
Oluf Pedersen - University of Copenhagen
Nilesh J. Samani - University of Leicester
Thorkild I. A. Sorensen - University of Copenhagen
Ryoichi Takayanagi - Kyushu University
Daniela Toniolo - Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy
Habibul Ahsan - University of Chicago
Hooman Allayee - Supreme Council Of Health
Yuan-Tsong Chen - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
John Danesh - University of Cambridge
Ian J. Deary - University of Edinburgh
Oscar H. Franco - College Station Medical Center
Lude Franke - University of Groningen
Bastiaan T. Heijman - Leiden University
Joanna D. Holbrook - ASTAR, Singapore Inst Clin Sci, Singapore, Singapore
Aaron Isaacs - College Station Medical Center
Bong-Jo Kim - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do, South Korea
Xu Lin - Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China
Jianjun Liu - Supreme Council Of Health
Winfried Maerz - University of Mannheim
Andres Metspalu - University of Tartu
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Dharambir K. Sanghera - University of Oklahoma
Xiao-Ou Shu - Vanderbilt University
Joyce B. J. van Meurs - College Station Medical Center
Eranga Vithana - Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore
Ananda R. Wickremasinghe - University of Kelaniya
Cisca Wijmenga - University of Groningen
Bruce H. W. Wolffenbuttel - University of Groningen
Mitsuhiro Yokota - Aichi Gakuin University
Wei Zheng - Vanderbilt University
Dingliang Zhu - Shanghai Jiao Tong University
Paolo Vineis - University of London
Soterios A. Kyrtopoulos - College Station Medical Center
Jos C. S. Kleinjans - Maastricht University
Mark I. McCarthy - University of Oxford
Richie Soong - Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117548, Singapore
Christian Gieger - Helmholtz Zentrum München
James Scott - University of London
Yik-Ying Teo - Supreme Council Of Health
Jiang He - Tulane University
Paul Elliott - University of London
E. Shyong Tai - Supreme Council Of Health
Pim van der Harst - University of Groningen
Jaspal S. Kooner - Ealing Hosp Natl Hlth Serv NHS Trust, Southall, Middx, England
John C. Chambers - University of London
InterAct Consortium
Publication Details: Nature genetics, Vol.47(11), pp.1282-1293
Publisher: Springer Nature
Number of pages: 14
Grant note: 310 / Helmholtz-Russia Joint Research Group (HRJRG) DK078150; TW05596; HL085144; TW008288 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Danish Pharmaceutical Association Pahlssons Foundation 2001 D 032 / Netherlands Heart Foundation Emil Aaltonen Foundation 17C-1; 20S-6 / Grants for International Health Research from the Ministry of Health, Labour and Welfare of Japan 104781; 120315; 129269 / Academy of Finland (Center of Excellence in Complex Disease Genetics); Research Council of Finland Health and Labor Sciences Research Grants, Japan 24390084; 21390099; 20390185; 22390186; 24591060; 25253059; 25461127 / Grants for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan Ministry of Health, Ricerca Finalizzata; Ministry of Health, Italy; Ministry of Health Italy - Ricerca Finalizzata (MOH-RF) ALK-Abello (Horsholm, Denmark) Centre National de Genotypage from Merck Co. 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RG/07/008/23674 / British Heart Foundation Merck Co.; Merck & Company G0601966; G0700931; G0500539; G0600331; G0902037 / Medical Research Council, UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 184.021.007 / Netherlands Organization for Scientific Research (NWO project); Netherlands Organization for Scientific Research (NWO) Aase and Ejner Danielsens Foundation VPR bridge grant from the University of Oklahoma Health Sciences Center H15-Longevity-005; H17-Longevity-003; H16-Kenko-001; H18-Longevity(kokusai); H11-Longevity-020; H17-Kenkou-007; H17-Pharmaco-common-003; H18-Junkankitou[Seishuu]-Ippan-012; H20-Junkankitou[Seishuu]-Ippan-009; 013 / Ministry of Health, Labor and Welfare of Japan; Ministry of Health, Labour and Welfare, Japan HS06516 / Agency for Health Care Policy Research; United States Department of Health & Human Services; Agency for Healthcare Research & Quality Skane Regional Health Authority 370062002 / NUS-HUJ CREATE Programme of the National Research Foundation, Singapore; 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279143; 201668; 305739; LSHM-CT-2004-503485 / European Union; European Union (EU) German-Israeli Foundation for Scientific Research and Development 75617 / University of Oulu, Finland European Commission (DG XII); European Union (EU); European Commission Joint Research Centre Lundbeck Foundation Centre for Applied Medical Genomics in Personalised Disease Prediction, Prevention and Care (LuCamp) 2009AA022703; 2006AA022179 / Chinese National High-Tech Program (863); National High Technology Research and Development Program of China 2011-PDR-13 / Fondazione con il SUD Royal Society ENGAGE project Genome Institute of Singapore BB/F019394/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 084723/Z/08/Z / Wellcome Trust 30871361 / Ministry of Science and Technology, National Natural Science Foundation of China NRF-RF-2010-05 / National Research Foundation of Singapore; National Research Foundation, Singapore Yong Loo Lin School of Medicine; National University of Singapore Federal Ministry of Health Economic Structure-Enhancing Fund (FES) of the Dutch government Research Centre for Prevention and Health Timber Merchant Vilhelm Bangs Foundation Juho Vainio Foundation Danish Research Council; Det Frie Forskningsrad (DFF) Singapore Institute for Clinical Sciences, A*STAR, Singapore; Agency for Science Technology & Research (A*STAR) Erasmus Medical Center Netherlands Organization for Health Research and Development (ZonMw); Netherlands Organization for Health Research and Development NWO 184.021.007 / Dutch government Dutch Interuniversity Cardiology Institute Netherlands (ICIN) British Heart Foundation Chief Scientist Office of the Scottish government G51 / RNID Swedish Research Council A28 / INTERREG IV Oberrhein Program (Genetic Mechanisms of Cardiovascular Diseases) Biomedical Research Council of Singapore (under the individual research grants scheme); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Wissenschaftsoffensive TMO 286284; 134309; 126925; 121584; 124282; 129378; 117787; 41071 / Academy of Finland; Research Council of Finland Munich Center of Health Sciences (MC Health), LMUinnovativ Program for the Promotion of Fundamental Studies in Health Sciences, National Institute of Biomedical Innovation Organization (NIBIO) 5R01HL087679-02; 1RL1MH083268-01 / National Heart, Lung, and Blood Institute through the STAMPEED program Takeda Medical Research Foundation Health Science Research Grants and Medical Technology Evaluation Research Grants from the Ministry of Health, Labour and Welfare of Japan Pfizer Uehara Memorial Foundation Helmholtz Zentrum Munchen-German Research Center for Environmental Health; Helmholtz Association 050-060-810 / Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging grant) Velux Foundation; Velux Fonden Oxford British Heart Foundation Centre of Research Excellence 9M048; 9N035 / Competitive Research Funding from Tampere University Hospital 175.010.2007.006 / Netherlands Organization for Health Research and Development (NWO-Groot grant) Augustinus Foundation Erasmus University STaR/0003/2008; CG/SERI/2010; NMRC/1270/2010; 0796/2003; IRG07nov013; IRG09nov014 / NMRC, Singapore; National Medical Research Council, Singapore Novo Nordisk Foundation; Novocure Limited NMRC of Singapore; National Medical Research Council, Singapore Japanese Atherosclerosis Prevention Fund province of Groningen, University Medical Center Groningen NMRC/TCR/012-NUHS/2014 / Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme; National Research Foundation, Singapore Compagnia di San Paolo (Torino, Italy); Compagnia di San Paolo 90.700.441 / Netherlands Organization for Health Research and Development (ZonMw grant) E033 / Dutch Kidney Foundation Danish Heart Foundation University of Groningen UK Biotechnology and Biological Sciences Research Council (BBSRC); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Lundbeck Foundation; Lundbeckfonden Becket Foundation Life Sciences Institute of the National University of Singapore; National University of Singapore NOT-HG-11-009 / National Human Genome Research Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) Research Institute for Diseases in the Elderly (RIDE) Telethon, Italy; Fondazione Telethon 22S-10; 25S-1 / National Center for Global Health and Medicine; National Center for Global Health & Medicine - Japan MR/K013351/1; MR/K026992/1; 1241993; MC_UU_12015/1; MR/L003120/1; MC_UU_12013/1; G0800270; G0700931; G0802782; MR/L01341X/1; MC_U106179471; G0601966; MR/K002414/1; MR/M012638/1; G0902037; G0600331 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 5R01MH63706:02 / US NIH/National Institute of Mental Health P01HL098055; P01HL076491; R01HL103866; P20HL113452; R01HL103931 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 01EY1103 / German Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) CCM BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) German Ministry of Education and Research (BMBF) through the National Genome Research Network (NGFN); Federal Ministry of Education & Research (BMBF) 21390099; 20390185; 19659163; 16790336; 12204008; 15790293; 16590433; 17790381; 18390192; 18590265; 18590587; 18590811; 19590929; 19650188; 19790423; 17390186; 20390184; 21390223 / Ministry of Education, Culture, Sports, Science and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Stroke Association Genetic Laboratory of the Department of Internal Medicine, Erasmus Medical Center National University Health System GENDINOB project LSHM-CT-2006-037197 / European Union (Sixth Framework Programme of the European Community); European Union (EU); Marie Curie Actions U01HL072507; R01HL087263; R01HL090682 / National Heart, Lung, and Blood Institute, US NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions G51 / Action on Hearing Loss municipality of Rotterdam Japanese Science and Technology Agency; Japan Science & Technology Agency (JST) Danish Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NF-SI-0611-10136; NF-SI-0611-10170; NF-SI-0512-10165 / National Institute for Health Research; National Institutes of Health Research (NIHR) 16.54041; 18.54042; 19.7152; 20.7198; 20.7477; 20.54043 / Japanese Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-Economic Status and Health Capital Region of Denmark 5RO1AG13196 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Social Insurance Institution of Finland 2004CB518603; 2006CB503804; 2009CB521905 / Chinese National Key Program for Basic Research (973); National Basic Research Program of China Ministry of Economic Affairs R01DK082766 / US National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Novo Nordisk; Novo Nordisk Foundation MEKOS Laboratories Denmark 916.761.70 / Netherlands Organization for Health Research and Development (NWO VENI grant) Fondazione Cariplo, Italy; Fondazione Cariplo Finnish Foundation of Cardiovascular Research A*STAR, Singapore; Agency for Science Technology & Research (A*STAR) Fondazione Banco di Napoli Science and Technology Incubation Program in Advanced Regions FIRB-RBNE08NKH7 / Italian Ministry of Universities (Interomics Flag project) Finnish Foundation for Cardiovascular Research BMBF e:Med project e:AtheroSysMed-Systems Medicine of Myocardial Infarction and Stroke; Federal Ministry of Education & Research (BMBF) Science and Technology Incubation Program in Advanced Regions, Japanese Science and Technology Agency Center of Excellence in Genomics (EXCEGEN) Danish Agency for Science, Technology and Innovation Roche Vitamins, Ltd. Swedish Heart Lung Foundation; Swedish Heart-Lung Foundation Biocentrum Helsinki 4845-301; 4851-302; 4851-307 / Korean Centers for Disease Control and Prevention Ministry of Education, Culture and Science; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) BB/F019394/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 2012-N73002-00 / Korean National Institute of Health, Republic of Korea National Center for Global Health and Medicine; National Center for Global Health & Medicine - Japan Age UK (The Disconnected Mind project) Emil Aaltonen Foundation, Finland European Regional Development Fund (ERDF); European Union (EU) Research Foundation of Copenhagen County RP-PG-0407-10371 / NIHR; National Institutes of Health Research (NIHR) NIHR Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust Biomedical Innovation Grants 08/1/35/19/550; 09/1/35/19/616 / Biomedical Research Council of Singapore; Agency for Science Technology & Research (A*STAR)
Identifiers: 9939192208331
Academic Unit: King Abdulaziz University; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article