Abstract
Eleven cases of transnasal endoscopic resection of unilaterally occurring pleomorphic adenomas have thus far been reported. This in part is due to the rarity of the disease, but could also reflect on the technical challenge required for wide en bloc excision of such tumors from a relatively small and narrow nasal cavity. We report the case of a large pleomorphic adenoma of the nose, occupying both nasal cavities with destruction of the cartilaginous nasal septum, removed completely through an endoscopic transnasal approach. To our knowledge, this is the first reported case of endoscopic resection of a humongous pleomorphic adenoma arising from both sides of the nasal septum.