Tributyltin(IV)[3-(3 ',5 '-dimethylphenylamido)propanoate] as a potent HCV inhibitor, its delivery study, controlled release and binding sites using CTAB as a standard cell membrane

Farooq Ali Shah; Kaneez Fatima; Shaista Sabir; Saqib Ali; Ishtiaq Qadri

doi:10.1002/aoc.3079

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Tributyltin(IV)[3-(3 ',5 '-dimethylphenylamido)propanoate] as a potent HCV inhibitor, its delivery study, controlled release and binding sites using CTAB as a standard cell membrane

Journal article

Peer reviewed

Tributyltin(IV)[3-(3 ',5 '-dimethylphenylamido)propanoate] as a potent HCV inhibitor, its delivery study, controlled release and binding sites using CTAB as a standard cell membrane

Farooq Ali Shah, Kaneez Fatima, Shaista Sabir, Saqib Ali and Ishtiaq Qadri

Applied organometallic chemistry, Vol.28(2), pp.74-80

02/2014

DOI: https://doi.org/10.1002/aoc.3079

Abstract

Chemistry

Chemistry, Applied

Chemistry, Inorganic & Nuclear

Physical Sciences

Science & Technology

Gaussia luciferase assay was used to measure the anti-hepatitis C (anti-HCV) potency of tributyltin(IV)[3-(3,5-dimethylphenylamido)propanoate] in infected Huh 7.5 cells (human hepatocellular cell). Interaction of the organotin(IV) complex with cetyl N,N,N-trimethylammonium bromide (CTAB) micelles was studied using UV-visible and steady-state florescence spectroscopy. The anti-HCV study showed a log IC50 value of 0.96nm for the complex. The complex-CTAB interaction parameter showed that partition of the complex from bulk water to the CTAB micelle was a spontaneous process, and the red shift in visible spectra of the complex confirmed its increased solubility into micelles. Copyright (c) 2013 John Wiley & Sons, Ltd.

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Title: Tributyltin(IV)[3-(3 ',5 '-dimethylphenylamido)propanoate] as a potent HCV inhibitor, its delivery study, controlled release and binding sites using CTAB as a standard cell membrane
Creators - without role: Farooq Ali Shah - Quaid-i-Azam University
Kaneez Fatima - IQ Inst Infect & Immun, Lahore, Pakistan
Shaista Sabir - Allama Iqbal Open University
Saqib Ali - Quaid-i-Azam University
Ishtiaq Qadri - King Abdulaziz University
Publication Details: Applied organometallic chemistry, Vol.28(2), pp.74-80
Publisher: Wiley
Number of pages: 7
Identifiers: 9940066608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article