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Trifluoroborane catalyzed chemoselective synthesis of highly functionalized 1,3-thiazin-2-ylidenes
Journal article   Peer reviewed

Trifluoroborane catalyzed chemoselective synthesis of highly functionalized 1,3-thiazin-2-ylidenes

Zhibin Luo, Sangepu Bhavanarushi, Avula Sreenivas, Narra Srikanth Reddy, Anil Valeru, Imran Khan, Yin Xu, Bin Liu and Jimin Xie
Journal of heterocyclic chemistry, Vol.57(9), pp.3334-3341
09/2020

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient chemoselective synthesis of 1,3-thiazine-2-ylidenes was achieved via annulations of beta-aroyl-thioacetamide with propargyl alcohols using BF(3)OEt(2)as Lewis acid catalyst. A broad spectrum of substrates was well tolerated under the mild reaction conditions producing desired thiazine heterocyclics in good yields.

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