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Trisomy 8 mosaicism in a patient with heterotaxia
Journal article   Peer reviewed

Trisomy 8 mosaicism in a patient with heterotaxia

Fowzan S Alkuraya and David J Harris
Birth defects research. A Clinical and molecular teratology, Vol.73(1), pp.58-60
01/2005
PMID: 15578648

Abstract

Chromosomes, Human, Pair 8 Esophagus - abnormalities Esophagus - diagnostic imaging Female Humans Infant Infant, Newborn Radiography Trisomy - physiopathology Viscera - abnormalities
Constitutional trisomy 8 mosaicism (CT8M) is a relatively rare trisomy in humans with a characteristic phenotype. We report an infant with the characteristic CT8M phenotype in addition to heterotaxia. A number of chromosomal abnormalities have been reported in association with laterality defects but this is the first time heterotaxia is reported in CT8M. In addition to expanding CT8M phenotype, our report may provide insight into the mechanism of heterotaxia.

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