Abstract
The endophytic fungus No. 1893 was isolated from the dropper of
Kandelia candel from an estuarine mangrove on the South China Sea coast. The ethyl acetate extract of the fermentation broth of this fungus strain exhibited cytotoxicity toward NCI4460 and Bel-7402, and high activities against
Heliothis armigera (Hühner) and
Sinergasilus spp. Two new lactones, 1893A (
1
) and B (
2
), together with 5-(
p-hydroxybenzyl)hydantoin and two cyclodipeptides, cyclo-(Ser-Leu) and cyclo-(Phe-Gly), were isolated from the extract. Their structures were determined by spectroscopic experiments, including X-ray diffraction.
The ethyl acetate extract of the endophytic fungus No. 1893 exhibited cytotoxicity toward NCI4460 and Bel-7402, and high activities against plumule and water spider. Two new lactones, 1893A (
1
) and B (
2
), together with 5-(
p-hydroxybenzyl)hydantoin and two cyclodipeptides, cyclo-(Ser-Leu)and cyclo-(Phe-Gly), were isolated from the extract. The structures of
1
and
2
were determined by spectroscopic and X-ray diffraction experiments.