Abstract
Two new polyacetylenes (
and
), along with two known C-30 steroids (
and
) were identified from the Red Sea sponge,
sp. The chemical structures were determined based on extensive spectroscopic measurements 1D (
H,
C and DEPT) and 2D (COSY, HSQC and HMBC) NMR, UV, IR and MS. The new compounds
and
were evaluated for their antimicrobial and antitumor activities.
and
were active against multidrug- resistant bacteria with MICs ranged from 2.2 to 4.5 μM. No toxicity was recorded for the two tested compounds up to 5 μM using
as a test organism. Compound
showed excellent antifungal activity against some pathogenic fungi such as
and
(MIC 2.2–2.5 μM) and antitumor activity against both Ehrlich ascites carcinoma and lymphocytic leukemia (LD
5.0 μM).