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UV Light-mediated regioselective methylsulfanyl discrimination via Pd-catalyzed cross-coupling reactions of 2,4-dimethylsulfanylpyrido[2,3-d]pyrimidines
Journal article   Peer reviewed

UV Light-mediated regioselective methylsulfanyl discrimination via Pd-catalyzed cross-coupling reactions of 2,4-dimethylsulfanylpyrido[2,3-d]pyrimidines

Yassine Riadi
Journal of sulfur chemistry, Vol.40(4), pp.351-360
04/07/2019
DOI: https://doi.org/10.1080/17415993.2019.1590581

Abstract

Liebeskind-Srogl methylsulfanyl discrimination Photochemical pyridopyrimidines regioselective
An effective and novel photochemical method for the preparation of 2,4-disubstituted pyrido[2,3-d]pyrimidines is reported from 2,4-dimethylsulfanyl-pyrido[2,3-d]pyrimidines through a Liebeskind-Sroglcoupling reaction involving an original selective methyl sulfanyl discrimination using UV light as a source of energy. Our strategies involve a two-step and a one-pot approach with reaction times of 11-18 h and yields ranging between 72 and 94%. The two strategies are compared.

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