Abstract
Two simple and sensitive spectroscopic methods in ultraviolet and visible region were developed for the estimation of metadoxine in pharmaceutical dosage forms. Method A is based on metadoxine, showing absorbance at 290 nm in distilled water. The method B is based on the reaction of metadoxine with 1.5% w/v (2 mL) solution of ferric nitrate reagent, to yield a yellow orange colour. This colour has characteristic light absorption in the visible region, with absorption maximum at 445 nm. These methods obeys Beers law in the concentration range of 2 to 28 and 10 to 100 mu g/mL, respectively.