Abstract
The voltammetric behavior of the Gemifloxacin mesylate (GFX) on hanging mercury dropping electrode (HMDE) was studied using three different voltammetry modes. A well-defined cathodic peak was obtained in acetate buffer pH 5.0. An irreversible and diffusion controlled peak was characterized. The relationships between the current and the concentration of the investigated drug were plotted and displayed linearity over the concentration ranges of 0.01- 0.19 μg mL-1, 0.006 – 0.13 μg mL-1 and 0.008– 0.27 μg mL-1 with minimum detection limits of 1.49, 2.06 and 2.34 μg mL-1 using DPV, SWV and CV modes, respectively. The suggested electrochemical approaches were successfully used to determine GFX in commercial products such as tablets, and the outcome data were analyzed statistically and their agreement with those from previously conducted spectrophotometric method was evaluated. The simplicity and potential sensitivity of the suggested approaches allows the assay of GFX in the bio-media. The reaction pathway was postulated.