Abstract
In this study, novel carbon paste and modified carbon paste inclusion beta- cyclodextrin and carbon nanotubes sensors for determination of nimustine hydrochloride was introduced. Three different carbon paste sensors were fabricated based on the incorporation of nimustine hydrochloride with sodium tetraphenylborate to produce nimustine-tetraphenylborate as electroactive material. Ortho-nitrophenyloctyl ether (o-NPOE) was added as plasticizer. Sensor I was a conventional carbon paste type, while sensor II and III were modified carbon sensors using beta-cyclodextrin and carbon nanotubes, respectively. The fabricated sensors were displayed Nernstian responses 55.8+/-0.8, 57.7+/-0.3 and 58.2+/-0.1 mV decade(-1) over concentration ranges of 1.0x10(-5)-1.0x10(-2), 1.0x10(-7)-1.0x10(-2) and 1.0x10(-8)-1.0x10(-2) mol L-1 for sensors I, II and III, respectively. The detection limits were 4.8x10(-6), 5.0x10(-8) and 7.9x10(-9) mol L-1, respectively. The critical characteristics of the fabricated sensors were investigated. The developed method was validated according to ICH guidelines and the recorded data were statistically assessed and compared with those obtained from other reported methods.