Abstract
The present work aims to evaluate the anti-diabetic and anti-histamine activity of the synthesized benzimidazolo-1,3,5- triazine derivatives. These newly products have been synthesized under ultrasound irradiation with good yields and their structures were established by spectral data. The amylase inhibition assay and diclorofenac were used to evaluate the antidiabetic and antihistamine of all synthesized derivatives, respectively. It was shown that compounds 3c and 3e give the best of inhibition results of the amylase enzyme with respect to 2-aminobenzimidazole and other derivatives at a concentration of 1000 mu g/L, IC50 = 59.4 and 52.1, respectively. Furthermore, compounds 3e, 3f, 3d, and 3a give highly significant inhibition activity against histamine at various concentrations, IC50 = 25.6, 29.4, 101. 9, 121. 6, respectively, than compound 3c, 3b, and 2-aminobenzimidazole.