Abstract
Ultrasound-promoted reaction of substituted 2,4-dichloroquinolines (
1
) with ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (
2
) in the presence of K
2
CO
3
as mild base at moderate temperatures leads to 2-chloroquinolin-4-pyrimidine carboxylate derivatives (
3
) with high regioselectivity. All the compounds synthesized were characterized by use of spectral data and screened for their antibacterial activity against two Gram-positive (
Staphylococcus aureus
,
Bacillus cereus
) and two Gram-negative (
Escherichia coli
and
Pseudomonas aeruginosa
) bacteria. Activity was moderate.