Abstract
Systemic lupus erythematosus is a chronic autoimmune condition that can attack almost any organ. In fact, its clinical manifestations and serological abnormalities are the most diverse one among other autoimmune diseases. An uncommon distinctive entity of this disease is lupus erythematosus profundus. Herein, we report a case of 14 years old female complained of a progressive lesion over her right arm that was ulcerated later. Lupus erythematosus profundus diagnosis was confirmed through multiple histopathological examination. Patient was started on hydroxychloroquine 200 mg twice daily, but she could not tolerate it. Accordingly, she was switched to methotrexate in addition to trimacinolone injection, as she showed more tolerance and improvement. The patient was seen for almost two years.