Abstract
Background and Aim: Many studies have shown a relationship between hyperuricemia, metabolic syndrome (MetS), and cardiovascular disease. However, there is a dearth of studies identifying this relationship in those with type 2 diabetes mellitus (T2DM). Therefore, in the current study, we assessed the prevalence of hyperuricemia in Saudi females with T2DM and studied the correlation between risen serum uric acid levels and MetS. Methods and Results: We adopted an epidemiological, cross-sectional design. Participants were women aged >= 35 years old (n = 200) living in Al Madinah Al Munawarah city. Biochemical factors relevant to diabetes were measured. These included serum uric acid levels, glucose levels, HbA1c, and lipid profiles. In female T2DM patients, the prevalence of hyperuricemia and MetS were 80% and 70%, respectively. We found positive correlations between cholesterol, triglyceride, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting insulin levels, and serum uric acid in our T2DM sample. A multiple linear regression model showed the risk of MetS to be positively correlated with higher levels of uric acid, triglycerides, and glucose, and with higher BMIs. Conclusion: Elevated levels of serum uric acid were associated with a higher incidence of MetS and associated symptoms in T2DM Saudi females. Routine evaluation of uric acid may help to prevent MetSrelated T2DM complications.