Abstract
Candida albicans forms part of the normal human commensal flora but has the ability to cause serious, invasive disease in those who are immunosuppressed. One of its key virulence determinants is its ability to transition from a yeast to a filamentous form. This article focuses on the utility of using the worm model, Caenorhabditis elegans, to study Candida pathogenesis. C. elegans provides an in vivo infection environment that is ideally suited to study the mechanisms of filamentation and its role in disease. Findings from the C. elegans-Candida model appear highly predictive of findings in a mammalian infection model.