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Use of nitrones in the synthesis of potential antihypercholesterolemic and antibacterial mono and tricyclic beta-lactams
Journal article   Peer reviewed

Use of nitrones in the synthesis of potential antihypercholesterolemic and antibacterial mono and tricyclic beta-lactams

A Basak, K R Rudra and HMM Bdour
Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry, Vol.42(6), pp.1508-1513
01/06/2003

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The hydroxyethyl group at C-3 of a number of monocyclic beta-lactams 2a-d is elaborated by a series of reactions to the appropriate side chain meant for acting as cholesterol absorption inhibitor without perturbing the sensitive beta-lactam moiety. In addition, a novel tricyclic beta-lactam 2e has also been synthesized using the nitrone cycloaddition approach.

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