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Utility of recombinant fragment C for assessment of anti-tetanus antibodies in plasma
Journal article   Open access  Peer reviewed

Utility of recombinant fragment C for assessment of anti-tetanus antibodies in plasma

Girija Ramakrishnan, Karl Pedersen, Denis Guenette, Joyce Sink, Rashidul Haque, William A Petri, Jr, Joel Herbein, Carol A Gilchrist and Essam Hassan Ibrahim
Diagnostic microbiology and infectious disease, Vol.82(1), pp.11-13
01/05/2015
DOI: https://doi.org/10.1016/j.diagmicrobio.2015.01.016
PMCID: PMC4991549
PMID: 25749462

Abstract

Antibodies, Bacterial - blood Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antitoxins - blood Child, Preschool Enzyme-Linked Immunosorbent Assay - methods Humans Infant Plasma - chemistry Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - isolation & purification Tetanus - immunology Tetanus - prevention & control Tetanus Toxin - genetics Tetanus Toxin - immunology
Anti-tetanus antibodies in biological samples are typically detected using an enzyme-linked immunosorbent assay based on toxoided tetanus neurotoxin as antigen. We demonstrate that recombinantly produced fragment C of the toxin heavy chain is an effective alternative antigen for assessment of tetanus-immune status in plasma samples.
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https://doi.org/10.1016/j.diagmicrobio.2015.01.016View
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