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Vancomycin Area Under the Curve and Acute Kidney Injury: A Meta-analysis
Journal article   Peer reviewed

Vancomycin Area Under the Curve and Acute Kidney Injury: A Meta-analysis

Doaa M Aljefri, Sean N Avedissian, Nathaniel J Rhodes, Michael J Postelnick, Kevin Nguyen and Marc H Scheetz
Clinical infectious diseases, Vol.69(11), pp.1881-1887
13/11/2019
DOI: https://doi.org/10.1093/cid/ciz051
PMCID: PMC6853683
PMID: 30715208

Abstract

and Commentaries AUC nephrotoxicity vancomycin
This meta-analysis identifies a clear exposure–response relationship (ie, area under the curve threshold greater than ~650 mg × hour/L) for vancomycin and acute kidney injury (AKI). It also suggests that area under the concentration-time curve monitoring strategies can potentially decrease the risk of AKI.

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