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Variability in Oral Desmopressin Dose Requirements in Children with Central Diabetes Insipidus
Journal article   Peer reviewed

Variability in Oral Desmopressin Dose Requirements in Children with Central Diabetes Insipidus

Nourah Almutlaq and Erica A Eugster
The Journal of pediatrics, Vol.239, pp.228-230
12/2021
DOI: https://doi.org/10.1016/j.jpeds.2021.08.087
PMID: 34487771

Abstract

Administration, Oral Adolescent Antidiuretic Agents - administration & dosage Antidiuretic Agents - therapeutic use Child Child, Preschool Deamino Arginine Vasopressin - administration & dosage Deamino Arginine Vasopressin - therapeutic use Diabetes Insipidus, Neurogenic - diagnosis Diabetes Insipidus, Neurogenic - drug therapy Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Infant Male Retrospective Studies Treatment Outcome
There is inconsistency in the amount of oral desmopressin that children with central diabetes insipidus require. We investigated whether clinical characteristics influenced desmopressin dose requirements in 100 children with central diabetes insipidus. Extremely large doses were associated with acquired etiology (P = .04), greater body mass index z score, intact thirst, and additional pituitary hormone deficiencies (P < .001).

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