Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series

Wael A. Alghamdi; Mohammad H. Al-Shaer; Kenneth P. Klinker; Charles A. Peloquin

doi:10.1002/ccr3.2835

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Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series

Journal article

Open access

Peer reviewed

Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series

Wael A. Alghamdi, Mohammad H. Al-Shaer, Kenneth P. Klinker and Charles A. Peloquin

Clinical case reports, Vol.8(7), pp.1126-1129

07/2020

DOI: https://doi.org/10.1002/ccr3.2835

PMID: 32695341

Abstract

efficacy

linezolid

monitoring

safety

thrombocytopenia

Two patients with normal renal function, yet each showed unexpected, supra‐ and subtherapeutic linezolid plasma concentrations resulting in toxicity and ineffective therapy, respectively. TDM helps to early identify and correct such excursions. Two patients with normal renal function, yet each showed unexpected, supra‐ and subtherapeutic linezolid plasma concentrations resulting in toxicity and ineffective therapy, respectively. TDM helps to early identify and correct such excursions.

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Title: Variable linezolid exposure and response and the role of therapeutic drug monitoring: Case series
Creators - without role: Wael A. Alghamdi - King Khalid University
Mohammad H. Al-Shaer - University of Florida
Kenneth P. Klinker - University of Florida
Charles A. Peloquin - University of Florida
Publication Details: Clinical case reports, Vol.8(7), pp.1126-1129
Number of pages: 4
Identifiers: 9922120208331
Academic Unit: King Khalid University
Language: English
Resource Type: Journal article