Abstract
Chemists found Imidazole as a multipurpose nucleus, primarily notable for its biological role in drug discovery. This compilation of the reports gives information regarding the development and the previous background of the synthesis of the nucleus. However, the synthesis through multicomponent is taken to narrow the report. The importance of the multicomponent reactions with many nucleus has been part of the heavy literature; however, the synthesis of the bioactive scaffold as imidazole has been highlighted here with the essential points. The emphasis of the review is to show the multicomponent approach where the multicomponent reaction plays a vital role in the formation of the ring. The MCR approaches align with modern-day drug discovery, where the library of the molecules is needed for drug development within a limited time frame. The multicomponent also comes under the green chemistry, where the reaction time and fewer reactions step plays a crucial role.