Abstract
Background: Vitamin B3 (Niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial.
Aim: To determine the effects of vitamin B3 with statins on lipid profile of patients of angina pectoris with dyslpidemia.
Study Design: Randomized control trial study.
Place and Duration of Study: Department of Biochemistry, Shaikha Fatima Institute of Nursing & Health Sciences (SFINHS), Lahore with collaboration of Cardiology OPD of Shaikh Zayed Hospital Lahore from 1st November 2019 to 31st January 2020.
Methodology: Seventy four diagnosed cases of angina pectoris with dyslipidemia were recruited with age range from 30 to 50 years. They were divided into two groups; Group I contained 36 patients as controlled group which was given treatment of angina with Tab. Rovista (statin) 10mg at dinner for treatment of dyslipidemia and Group II contained 38 patients as case study group which was given treatment of angina with Tab. Rovista (statin) 10 mg at dinner and tablet Vitamin B3 500 mg with single OD dose at day time for treatment of dyslipidemia for 8 weeks.
Results: The mean serum cholesterol levels at zero level (before the start of treatment) of group I was 244 mg/dl and group II was 246 mg/dl, LDL of group I was 169 mg/dl while group II was 170 mg/dl and HDL of group I was 20 mg/dl while group II was 19 mg/dl. After the treatment group I which taken only statins for treatment of dyslipidemia the mean serum cholesterol levels was 210 mg/dl, LDL was 144 mg/dl and HDL was 26 mg/dl while the mean values of group II (taken statin as well as vitamin B3) serum cholesterol level was 192 mg/dl, LDL was 122 mg/dl and HDL was 44 mg/dl. The results shown there were significant effects of statin therapy along with vitamin B3 on serum LDL and serum HDL levels.
Conclusion: There were significant effects of statin therapy along with vitamin B3 on serum LDL and Serum HDL levels.