Abstract
Vitamin D, a fat-soluble vitamin, plays a critical role in regulating plasma calcium concentration and may influence several non-skeletal medical conditions, including diabetes as well as other human diseases. The aim of this study was to determine the relationship between serum concentration of 25-hydroxy vitamin D 25 (OH) D3and both of glycemic profile and some of oxidative stress markers in diabetic patients compared to healthy subjects. The study included 84 subjects aged between 40-60 years divided into two main groups: Type 2 Diabetes Mellitus (T2DM) (n=43) and healthy subjects (n=41). Further classification of each group was carried out based on 25 (OH) D3status (deficient, insufficient and sufficient). Age was recorded and BMI was calculated. It was found that the prevalence of vitamin D deficiency was 44.18% and 56% for T2DM and control groups, respectively. Results indicated highly significant elevation in the mean values of FBG, HbA1c, FI, HOMA-IR, TG, MDA and AGEs in T2DM group compared to control group. Mean values of TAC, HDL were significantly decreased in T2DM compared to control group. Mean values of BMI, age, cholesterol, LDL and 25 (OH) D3 were not significantly changed in T2DM compared to control group. In control group, non-significant correlations were obtained for 25(OH) D3 with each tested parameter, however, in T2DM, 25(OH) D3 showed significant correlations with cholesterol and LDL. This study has shown that dyslipidemia, poor glycemic control and increased oxidative stress markers were highly prevalent among diabetic subjects. Though vitamin D deficiency was prevalent in T2DM and non-diabetic control subjects, its relationship to glycemic parameters and oxidative stress markers could not be confirmed, demonstrating that improvement in vitamin D status was not the only factor responsible for better health of the individuals but lifestyle and dietary changes seem to play a role, which will improve the overall health including hemoglobin glycation and insulin resistance along with vitamin D levels.