Abstract
Adsorptive stripping voltammetry was used to prospect the adsorption property of montelukast sodium (MKST) on the hanging mercury drop electrode (HMDE). Through appointing the adsorptive stripping voltammetric (AdSV) process, a sensitive electroanalytical method for the quantitative analysis of MKST was accomplished. A well-developed voltammetric peak was obtained in pH 10 Britton-Robinson buffer (B-R buffer) at -1.080 V. The cyclic voltammetric studies indicated that the reduction process was irreversible and primarily controlled by adsorption phenomena. The studies of the variation of adsorptive voltammetric peak current with buffer electrolyte, pH, accumulation time (t(acc)), accumulation potential (E-acc), sweep rate, pulse amplitude, square wave frequency, working electrode area and convection rate have evaluated in the recognition of optimal experimental conditions for MKST analysis. The studied electroanalytical signal showed a linear response for MKST in the concentration range 5x10-8- 1x10-6 mol L-1 (r = 0.994). A detection limit of 4x10-9 mol L-1 with relative standard deviation of 1.1 RSD% and mean recovery of 102%+/- 2.0 were obtained. The possible interferences by several compounds usually present in the pharmaceutical formulation were also evaluated. The analytical quantification of MKST drug in commercially available pharmaceutical formulation and biological samples was electrochemically studied.