Abstract
The electrochemical behavior of dropropizine at carbon paste electrodes was investigated in 0.04 M Britton-Robinson buffer pH 6.25 using cyclic and differential pulse voltammetric methods. Cyclic voltammetric studies indicated that the oxidation of dropropizine at the electrode surface was irreversible, and mainly controlled by diffusion. Based on this a sensitive and simple differential pulse voltammetric procedure has been developed for determination of the drug over the concentration range 0.24 -2.36 mu g/ml, with detection and quantification limits of 0.046 and 0.152 mu g/ml, respectively. The developed method was successfully applied to the determination of dropropizine in lozenges tablets, and spiked human urine.