Abstract
Adriblastina, a cancerostatic anthracycline antibiotic, causes considerable oxidative damage to
DNA molecules. The interaction of this compound with DNA was investigated using Osteryoung
square wave stripping voltammetry (OSWSV) and cyclic voltammetry (CV) at an in situ
mercury film electrode. It was found that the equilibrium constant of the bonded oxidized form
of the drug was 63 times bigger more important than that of the bonded reduced form. Copper
forms 1 metal: 2 drug stoichiometry complex which is highly stable compared to ssDNA-drug
interaction and consequently inhibited the drug biochemical damaging effects. Copper complex
offered sub-nanogram determination of adriblastina in aqueous and urine media. KCI Citation Count: 7