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Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation
Journal article   Open access  Peer reviewed

Water-mediated synthesis of disubstituted 5-aminopyrimidines from vinyl azides under microwave irradiation

Oussama Dehbi, Esam A. Ishak, Mohammed A. Bakht, Mohammed H. Geesi, Mohammed B. Alshammari, Vincent Chagnault, Abdellah Kaiba, Said Lazar and Yassine Riadi
Green chemistry letters and reviews, Vol.11(2), pp.62-66
03/04/2018
DOI: https://doi.org/10.1080/17518253.2018.1437225

Abstract

Chemistry Chemistry, Multidisciplinary Green & Sustainable Science & Technology Physical Sciences Science & Technology Science & Technology - Other Topics
An efficient and ecofriendly method for the synthesis of disubstituted 5-aminopyrimidines from vinyl azides and urea or thiourea was developed. This reaction proceeds under microwave irradiation conditions in the presence of water as a solvent. The remarkable features of this new protocol are high conversion, short reaction times, cleaner reaction profiles and straightforward procedure. [GRAPHICS]
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https://doi.org/10.1080/17518253.2018.1437225View
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