Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Jing Quan Lim; Dachuan Huang; Tiffany Tang; Daryl Tan; Yurike Laurensia; Rou-Jun Peng; Esther Kam Yin Wong; Daryl Ming Zhe Cheah; Burton Kuan Hui Chia; Jabed Iqbal; Nicholas Francis Grigoropoulos; Maarja-Liisa Nairismägi; Cedric Chuan Young Ng; Vikneswari Rajasegaran; Huangming Hong; Seok Jin Kim; Junhun Cho; Eric Tse; Benjamin Mow; Qi-Chun Cai; Li-Mei Poon; Qing-Qing Cai; Jing Tan; Jason Yongsheng Chan; Johnathan Xiande Lim; Yeow Tee Goh; Colin Phipps; Olaf Rötzschke; Chee Leong Cheng; Jeslin Chian Hung Ha; Lay Poh Khoo; Yvonne Su Ming Loh; Rex Au-Yeung; Thomas Sau-Yan Chan; Yok-Lam Kwong; William Hwang; Won Seog Kim; Jin-Xin Bei; Tongyu Lin; Choon Kiat Ong; Soon Thye Lim

doi:10.1038/s41375-020-1000-0

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$Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma$

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Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Jing Quan Lim, Dachuan Huang, Tiffany Tang, Daryl Tan, Yurike Laurensia, Rou-Jun Peng, Esther Kam Yin Wong, Daryl Ming Zhe Cheah, Burton Kuan Hui Chia, Jabed Iqbal, …

Leukemia, Vol.34(12), pp.3413-3419

01/12/2020

DOI: https://doi.org/10.1038/s41375-020-1000-0

PMCID: 7685978

PMID: 32753688

Abstract

Adult

Aged

Antibodies, Monoclonal, Humanized - therapeutic use

Female

Humans

Killer Cells, Natural - drug effects

Lymphoma, T-Cell - drug therapy

Lymphoma, T-Cell - genetics

Male

Middle Aged

Neoplasm Recurrence, Local - drug therapy

Neoplasm Recurrence, Local - genetics

Whole Genome Sequencing - methods

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Title: Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma
Creators - without role: Jing Quan Lim - National Cancer Centre Singapore
Dachuan Huang - National Cancer Centre Singapore
Tiffany Tang - National Cancer Centre Singapore
Daryl Tan - Singapore General Hospital
Yurike Laurensia - National Cancer Centre Singapore
Rou-Jun Peng - Sun Yat-sen University Cancer Center
Esther Kam Yin Wong - National Cancer Centre Singapore
Daryl Ming Zhe Cheah - National Cancer Centre Singapore
Burton Kuan Hui Chia - National Cancer Centre Singapore
Jabed Iqbal - Singapore General Hospital
Nicholas Francis Grigoropoulos - Singapore General Hospital
Maarja-Liisa Nairismägi - National Cancer Centre Singapore
Cedric Chuan Young Ng - National Cancer Centre Singapore
Vikneswari Rajasegaran - National Cancer Centre Singapore
Huangming Hong - Sun Yat-sen University Cancer Center
Seok Jin Kim - Samsung Medical Center
Junhun Cho - Samsung Medical Center
Eric Tse - Queen Mary Hospital
Benjamin Mow - Mount Elizabeth Hospital
Qi-Chun Cai - Guangdong Provincial People's Hospital
Li-Mei Poon - Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore
Qing-Qing Cai - Guangdong Academy of Medical Sciences
Jing Tan - Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore
Jason Yongsheng Chan - National Cancer Centre Singapore
Johnathan Xiande Lim - Singapore General Hospital
Yeow Tee Goh - Singapore General Hospital
Colin Phipps - Singapore General Hospital
Olaf Rötzschke - Singapore Immunology Network
Chee Leong Cheng - Singapore General Hospital
Jeslin Chian Hung Ha - National Cancer Centre Singapore
Lay Poh Khoo - National Cancer Centre Singapore
Yvonne Su Ming Loh - Singapore General Hospital
Rex Au-Yeung - Queen Mary Hospital
Thomas Sau-Yan Chan - Queen Mary Hospital
Yok-Lam Kwong - Queen Mary Hospital
William Hwang - National Cancer Centre Singapore
Won Seog Kim - Sungkyunkwan University
Jin-Xin Bei - Sun Yat-sen University Cancer Center
Tongyu Lin - Sun Yat-sen University Cancer Center
Choon Kiat Ong - Genome Institute of Singapore
Soon Thye Lim - Duke-NUS Medical School
Publication Details: Leukemia, Vol.34(12), pp.3413-3419
Identifiers: 9944989008331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article