Abstract
Diabetes and associated renal damage are major global threats. Almost every diabetic patient suffers from renal complications. With all that in mind, we have tried to investigate the anti-diabetic potential of a nano-formulation of Withania coagulans extract (WGNF-5) against streptozotocin-induced oxidative stress and renal damage in vivo. The treatment was given to five groups of animals (n = 6). The effects of test formulation at a dose of 5 mg/kg said WGNF-5 on blood glucose levels and renal functions were estimated. Animals were sacrificed, the isolated kidney was used for the examination of oxidative stress, inflammatory cytokines, and histopathological changes. Diabetes induction significantly elevated blood glucose, renal injury markers, inflammatory cytokines, and dropped the antioxidant enzymes. Treatment with WGNF-5, on the other hand, resulted in a substantial reduction in blood glucose levels, improved biochemical and histological characteristics, and thus acted as an anti-diabetic and renal protective component. However, a more detailed study is needed to perform for bringing this drug from bench to bedside.
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