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Ytterbium(III)-Catalyzed Addition Reaction of Alkynyltrifluoroborate Salts to alpha-Imino Esters: Efficient Synthesis of beta-Unsaturated alpha-Amino Esters
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Ytterbium(III)-Catalyzed Addition Reaction of Alkynyltrifluoroborate Salts to alpha-Imino Esters: Efficient Synthesis of beta-Unsaturated alpha-Amino Esters

Helio A. Stefani, Flavia Manarin, Amna N. Khan and Stanley N. S. Vasconcelos
European journal of organic chemistry, Vol.2014(6), pp.1236-1240
01/02/2014

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
We describe the development of a mild and efficient method for the preparation of -unsaturated -amino esters through the ytterbium triflate catalyzed addition of potassium alkynyltrifluoroborate salts to imino esters. The synthetic viability of this protocol was supported by its high yields, short reaction times, and efficiency with regard to the scope of the substrates.

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