Sign in
Back
ZnCl2-catalyzed three-component domino reactions for the synthesis of pyrano[3,2-c]quinolin-5(6H)-ones
Journal article   Peer reviewed

ZnCl2-catalyzed three-component domino reactions for the synthesis of pyrano[3,2-c]quinolin-5(6H)-ones

Pethaiah Gunasekaran, Pitchaimani Prasanna, Subbu Perumal and Abdulrahman I. Almansour
Tetrahedron letters, Vol.54(25), pp.3248-3252
19/06/2013
DOI: https://doi.org/10.1016/j.tetlet.2013.04.022

Abstract

4-Hydroxy-1-methylquinolin-2(1H)-one N-Methyl-1-(methylthio)-2-nitroprop-1-en-1-amine Pyrano[3,2-c]quinolin-5(6H)-ones Three-component reactions Zinc chloride
The ZnCl2-catalyzed three-component synthesis of pyrano[3,2-c]quinolin-5(6H)-ones from the domino reactions of 4-hydroxy-1-methylquinolin-2(1H)-one, nitroketene N,S-methylacetal, and aromatic aldehydes in ethanol in good yields is described. This domino transformation leads to the formation of one ring by creation of two C–C bonds and one C–O bond in a single synthetic operation.

Metrics

1 Record Views

Details