Abstract
N-Protected-(aminoacyl)benzotriazoles 1a-e,g,i,j,1a'-c' convert heterocyclic amines of the following series: thiazoles (3a and 3a'), benzothiazoles (3b and 3b'), benzimidazoles (3c and 3c'), thiadiazoles (3d), pyrimidones (9a,b,a'), pyrazoles (11a,b), and pyridines (13a-g, 13d') under microwave irradiation, into N-substituted amides in yields of 40-98% (average 76%). N-Protected peptidoylbenzotriazoles 6a,b similarly afforded C-terminal N-protected dipeptidoyl amides 7a,b (52-60%).