Abstract
Klebsiella pneumoniae causes infections especially in hospital environment. Emergence of antibiotics resistance among K. pneumoniae is a global concern. Resistance through Carbapenemase production reported in K. pneumoniae. The purpose of the study is to find the frequency of K. pneumoniae, related antibiogram, and phenotypic and molecular detection of carbapenemases. A total of 5475 samples were processed for culture, in which 1140 exhibited bacterial growth. Among 1140 culture positive samples, 110 isolates were K. pneumoniae. Phenotypic and molecular methods were used for detection of carbapenemases. All the isolates were resistant to Fosfomycin, cefotaxime, gentamicin and cloxacillin. 65.4% (n=72) isolates were resistant to meropenem and 57.2% (n=63) to imipenem. blaNDM gene was most prevalent (22.7%) followed by blaKPC (13.6%); however, blaOXA-48 was detected in one isolate. In the undertaken study, antibiotic resistance was increasingly observed in K. pneumaniac through carbapenemases. The current work will help to devise an appropriate antibiotic hospital policy to reduce K. pneumoniae resistance burden.