Abstract
A general, highly efficient, and green protocol for the synthesis of biologically important spiro[indoline‐3,4′‐pyrano[3,2‐c]chromene derivatives is developed by one‐pot, three‐component approach involving substituted isatin, active methylene group, and 4‐hydroxy coumarin. This report describes the use of γ‐valerolactone as a green reaction media for a variety of substrates. The advantageous features of this methodology are the environmentally benign character, operational simplicity, high yield processing (91–96%), easy handling, and the reaction medium can be recycled and reused several times without significant loss of its efficiency.