Abstract
Background: Knee osteoarthritis is a condition which cannot be treated easily even surgery isn’t a good option due to obesity and other comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA.
Objective: Review of articles to calculate the current evidence about regenerative medicine therapies in the treatment of KOA.
Methods: An online search of PubMed and Cochrane library database was performed to find out related literature using the keywords of “treatment, stem cell, knee osteoarthritis,” limited to the English language. Only those articles were recruited which met the inclusion criteria rest were filtered out.
Results: Out of 268 articles, only 18 articles met the inclusion criteria and were included in this study.
Limitation: There is still less literature about the efficacy of regenerative medicine in the treatment of KOA. Large clinical trials are required to make sure about the evidence.
Conclusion:
Current investigations conclude that regenerative medicine procedures have good evidence in the treatment of knee osteoarthritis. But still in greater depth study to explore more ideal way to overcome present difficulties is required.
Key words: Knee osteoarthritis, platelet rich plasma, stem cell, cartilage degeneration.