Abstract
Background: There has been an increase in number of obese infertile
females booked for advanced infertility treatment procedures like in
vitro fertilization (IVF) and intra cytoplasmic sperm injection (ICSI).
The knowledge of impact of body mass index (BMI) on reproductive
outcome can help to counsel these patients. Objective: To compare
reproductive outcome in females of different BMI after ICSI. Materials
and Methods: Cross-sectional study of 323 females was conducted from
June 2010 till August 2011. Females were grouped on the basis of BMI;
underweight, (BMI <18 kg/m2), normal weight, (BMI 18-22.9 kg/m2)
overweight (BMI 23-25.9 kg/m2) and obese (BMI ≥26 kg/m2). The
procedure involved down regulation of ovaries, controlled ovarian
stimulation, ovulation induction by hCG, oocyte pickup, in vitro
fertilization and embryo transfer of blastocysts. The oocyte yield and
embryological data of all BMI groups was compared by ANOVA (analysis of
variance). Pregnancy outcome of these was categorized as; no conception
βhCG <5 m IU/ml, preclinical abortion with βhCG >5 m
IU/ml, no cardiac activity on trans vaginal scan (TVS) and clinical
pregnancy with βhCG >5mIU/ml and cardiac activity on trans
vaginal scan. Results: Females with BMI 23-25.99 kg/m2 had maximum
oocyte retrieval, fertilization, implantation and clinical pregnancy
rates in comparison to obese females with BMI ≥26 kg/m2.
Conclusion: A BMI cut off value of above 26 kg/m2 in our study
population is associated with a negative impact on pregnancy outcome.